2,5-diethylbenzaldehyde | 1071619-00-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-diethylbenzaldehyde
• CAS: 1071619-00-5
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: WEPOLUVBIAQQNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,5-diethylbenzaldehyde 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.25h， 以630 mg的产率得到2,5-diethylbenzyl alcohol
  参考文献：
  名称：

  对Lavendustin A衍生的新型抗增殖剂的结构活性关系研究。第一部分：环A修饰。

  摘要：

  有效的抗增殖剂SDZ LAP 977在光化性角化病患者的临床概念验证研究中已显示出功效，先前已证明它可以阻断有丝分裂中的细胞周期。在本研究中，我们进一步探讨了作用方式：SDZ LAP 977与微管蛋白上的“秋水仙碱结合位点”结合，从而在体外抑制微管蛋白的聚合。此外，我们建立了结构-活性关系，以用于修饰分子的2，5-二甲氧基苯基部分（“环A”）对体外抗增殖活性的影响。

  DOI：

  10.1016/j.bmc.2008.07.039
• 作为产物：
  描述：

  1,4-二乙基苯 、 乌洛托品 在 三氟乙酸 作用下， 以54%的产率得到2,5-diethylbenzaldehyde
  参考文献：
  名称：

  对Lavendustin A衍生的新型抗增殖剂的结构活性关系研究。第一部分：环A修饰。

  摘要：

  有效的抗增殖剂SDZ LAP 977在光化性角化病患者的临床概念验证研究中已显示出功效，先前已证明它可以阻断有丝分裂中的细胞周期。在本研究中，我们进一步探讨了作用方式：SDZ LAP 977与微管蛋白上的“秋水仙碱结合位点”结合，从而在体外抑制微管蛋白的聚合。此外，我们建立了结构-活性关系，以用于修饰分子的2，5-二甲氧基苯基部分（“环A”）对体外抗增殖活性的影响。

  DOI：

  10.1016/j.bmc.2008.07.039

文献信息

• COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR
  申请人：HUMAN BIOMOLECULAR RESEARCH INSTITUTE

  公开号：US20160038641A1

  公开（公告）日：2016-02-11

  Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, transdifferentiation, and proliferation of animal cells into the osteoblast blast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of Formula II, IV, and VI independently or preferably in combination with a matrix to afford bone cells. Small molecule-stimulated cells were also combined with a matrix, placed with a cellular adhesive or material carrier and implanted to a site in an animal for bone repair. Matrix pretreated with compounds of Formula II, IV, and VI were also used to cause cells to migrate to the matrix that is of use for therapeutic purposes.

  描述了由小分子、基质和孤立细胞组成的组合物，包括制备方法，以及动物细胞分化、转分化和增殖成骨母细胞谱系的方法。给细胞施加的或与细胞共培养的成骨材料的示例由独立或首选与基质组合的Formula II、IV和VI化合物代表。受小分子刺激的细胞还与基质结合，与细胞粘合剂或材料载体一起植入到动物体内的部位进行骨修复。预先用Formula II、IV和VI化合物处理的基质也被用于导致细胞迁移到用于治疗目的的基质上。
• CHALCONE DERIVATIVE COMPOUNDS
  申请人：NIPPON OIL AND FATS COMPANY, LIMITED

  公开号：EP0328669A1

  公开（公告）日：1989-08-23

  Chalcone derivative compounds represented by general formula (I) or (II), wherein R₁ and R₂ each represents a ha­logen atom, a hydroxy group, an amino group, a dimethylamino group, a nitro group, a cyano group, a phenyl group, an acetyl group, an alkyl group containing 1 to 18 carbon atoms or an alkyloxy group containing 1 to 22 carbon atoms, n₁ and n₂ each represents an integer of 0 to 21, and m₁ and m₂ each represents an integer of 0 to 5.

  通式(I)或(II)代表的查耳酮衍生物化合物，其中 R₁ 和 R₂ 各自代表卤素原子、羟基、氨基、二甲基氨基、硝基、氰基、苯基、乙酰基、含 1 至 18 个碳原子的烷基或含 1 至 22 个碳原子的烷氧基，n₁ 和 n₂ 各自代表整数、乙酰基、含 1 至 18 个碳原子的烷基或含 1 至 22 个碳原子的烷氧基，n₁ 和 n₂ 各自代表 0 至 21 的整数，m₁ 和 m₂ 各自代表 0 至 5 的整数。
• Compounds and matrices for use in bone growth and repair
  申请人：HUMAN BIOMOLECULAR RESEARCH INSTITUTE

  公开号：US10874766B2

  公开（公告）日：2020-12-29

  Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, trans-differentiation, and proliferation of animal cells into the osteoblast blast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of Formula II, IV, and VI independently or preferably in combination with a matrix to afford bone cells. Small molecule-stimulated cells were also combined with a matrix, placed with a cellular adhesive or material carrier and implanted to a site in an animal for bone repair. Matrix pretreated with compounds of Formula II, IV, and VI were also used to cause cells to migrate to the matrix that is of use for therapeutic purposes.

  描述了小分子、基质和分离细胞的组合物，包括制备方法，以及将动物细胞分化、转分化和增殖为成骨细胞的方法。向细胞施用或与细胞共培养的成骨材料的例子以式 II、IV 和 VI 的化合物为代表，这些化合物可独立使用，或最好与基质结合使用，以产生骨细胞。小分子刺激的细胞也与基质结合，与细胞粘合剂或材料载体一起放置，并植入动物的骨修复部位。用式 II、IV 和 VI 的化合物预处理的基质也用于使细胞迁移到用于治疗目的的基质上。
• EP3038621A2
  申请人：——

  公开号：EP3038621A2

  公开（公告）日：2016-07-06
• [EN] COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR<br/>[FR] COMPOSÉS ET MATRICES POUR UNE UTILISATION DANS LA RÉPARATION ET LA CROISSANCE DES OS
  申请人：HUMAN BIOMOLECULAR RES INST

  公开号：WO2014146039A2

  公开（公告）日：2014-09-18

  Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, trans-differentiation, and proliferation of animal cells into the osteoblast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of Formula II, IV, and VI independently or preferably in combination with a matrix to afford bone cells. Small molecule-stimulated cells were also combined with a matrix, placed with a cellular adhesive or material carrier and implanted to a site in an animal for bone repair. Matrix pretreated with compounds of Formula II, IV, and VI were also used to cause cells to migrate to the matrix that is of use for therapeutic purposes.