adamantan-1-carboxylic acid benzo[1,3]dioxol-5-ylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: adamantan-1-carboxylic acid benzo[1,3]dioxol-5-ylamide
• 英文别名: N-(1,3-Benzodioxol-5-yl)-1-adamantanecarboxamide；N-(1,3-benzodioxol-5-yl)adamantane-1-carboxamide
• 化学式: C₁₈H₂₁NO₃
• mdl: MFCD01832644
• 分子量: 299.37
• InChiKey: PDZHTAQPWOJAQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL ADAMANTANE DERIVATIVE COMPOUND
  申请人：Amorepacific Corporation

  公开号：EP3187486A1

  公开（公告）日：2017-07-05

  Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

  公开了一种新型金刚烷衍生物化合物、其异构体、其药学上可接受的盐、其原药、其水合物或其溶液。还公开了一种制备新型金刚烷衍生物化合物、其异构体、其药学上可接受的盐、其原药、其水合物或其溶液的方法。新型金刚烷衍生物化合物或类似物具有优异的抗雄激素作用。
• Adamantane derivative compound
  申请人：AMOREPACIFIC CORPORATION

  公开号：US10696611B2

  公开（公告）日：2020-06-30

  Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

  公开了一种新型金刚烷衍生物化合物、其异构体、其药学上可接受的盐、其原药、其水合物或其溶液。还公开了一种制备新型金刚烷衍生物化合物、其异构体、其药学上可接受的盐、其原药、其水合物或其溶液的方法。新型金刚烷衍生物化合物或类似物具有优异的抗雄激素作用。