9-(2-(p-tolyloxy) ethyl)-9H-purin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(2-(p-tolyloxy) ethyl)-9H-purin-6-amine
• 英文别名: 9-(2-p-Tolyloxy-ethyl)-9H-purin-6-ylamine；9-[2-(4-methylphenoxy)ethyl]purin-6-amine
• 化学式: C₁₄H₁₅N₅O
• 分子量: 269.306
• InChiKey: WQRGFXWTNZARPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  78.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-chloro-9-(2-(p-tolyloxy)ethyl)-9H-purine 在 ammonium hydroxide 作用下， 以96 %的产率得到9-(2-(p-tolyloxy) ethyl)-9H-purin-6-amine
  参考文献：
  名称：

  一种嘌呤类衍生物及其用途

  摘要：

  本发明涉及一种嘌呤类衍生物及其用途，该衍生物的结构式如式(I)或式(II)所示。该化合物表现出良好的NSD2、NSD3抑制活性，在细胞内可有效地降低H3K36的甲基化水平，并引起NSD2、NSD3高表达肿瘤细胞株的细胞增殖活性的降低，可以作为NSD2和NSD3抑制剂。#imgabs0#

  公开号：

  CN116903623A

文献信息

• Photoreactive ligands and uses thereof
  申请人：The Scripps Research Institute

  公开号：US11535597B2

  公开（公告）日：2022-12-27

  Disclosed herein are methods for identifying proteins as targets for interaction with a small molecule ligand. Also disclosed herein are small molecule ligands and compositions for use in profiling druggable proteins.

  本文公开了用于确定蛋白质作为与小分子配体相互作用的靶标的方法。本文还公开了用于分析可药用蛋白质的小分子配体和组合物。
• Discovery of potent small molecule inhibitors of histone lysine methyltransferase NSDs
  作者：Lianhua Piao、Ying Gao、Xiaoshuang Xu、Yangyang Su、Yanong Daniel Wang、Jie Zhou、Yang Gao、Jin Fang、Qihui Li、Shan Chang、Ren Kong

  DOI：10.1016/j.ejmech.2024.116264

  日期：2024.3
• Microrna modulators and method for identifying and using the same
  申请人：Huang Qihong

  公开号：US20100196357A1

  公开（公告）日：2010-08-05

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying And Using The Same
  申请人：Huang Qihong

  公开号：US20120010177A1

  公开（公告）日：2012-01-12

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying and Using the Same
  申请人：Huang Qihong

  公开号：US20130023498A1

  公开（公告）日：2013-01-24

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.