8-Quinolinecarboxanilide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-Quinolinecarboxanilide
• 英文别名: N-phenylquinoline-8-carboxamide
• 化学式: C₁₆H₁₂N₂O
• 分子量: 248.28
• InChiKey: QQYWGNSDNZBBJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• TREATMENT REGIME FOR PROLIFERATIVE DISORDERS
  申请人：Oncolytics Biotech Inc.

  公开号：EP2211880A1

  公开（公告）日：2010-08-04
• US3956420A
  申请人：——

  公开号：US3956420A

  公开（公告）日：1976-05-11
• US7767670B2
  申请人：——

  公开号：US7767670B2

  公开（公告）日：2010-08-03
• [EN] TREATMENT REGIME FOR PROLIFERATIVE DISORDERS<br/>[FR] RÉGIME DE TRAITEMENT POUR DES TROUBLES PROLIFÉRATIFS
  申请人：ONCOLYTICS BIOTECH INC

  公开号：WO2009052617A1

  公开（公告）日：2009-04-30

  Provided herein are methods for treating or ameliorating a proliferative disorder in a subject. The method contains the steps of administering to the subject one dose of an immunosuppressive agent followed by administering to the subject one to five doses of a reovirus. The immunosuppressive agent is administered to the subject at least about 72 hours prior to administration of the reovirus. Also provided herein are methods for treating or ameliorating a proliferative disorder in a subject including the steps of administering to the subject an oncolytic virus and a B-cell modulating agent. Also provided are kits and pharmaceutical compositions containing an oncolytic virus and at least one B-cell modulating agent.