2-(2-Cyanoacetyl)-N-(2-methoxyphenyl)hydrazine-1-carbothioamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-Cyanoacetyl)-N-(2-methoxyphenyl)hydrazine-1-carbothioamide
• 英文别名: 1-[(2-cyanoacetyl)amino]-3-(2-methoxyphenyl)thiourea
• 化学式: C₁₁H₁₂N₄O₂S
• 分子量: 264.31
• InChiKey: XVMXHLZQMRJCCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  87.5
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Antifungal compounds and uses thereof
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US11136291B2

  公开（公告）日：2021-10-05

  Provided herein are compounds (e.g., compounds of Formulae (I), (II), and (III)) which are anti-fungal agents and can be used in the treatment of diseases, including infectious diseases. The invention provides methods of treating diseases in a subject (e.g., infectious diseases such as fungal infections), and methods of killing or inhibiting the growth of fungi in or on a subject or biological sample. The compounds may be used in subjects, in clinical settings, or in agricultural settings.

  本发明提供的化合物（例如，式（I）、（II）和（III）化合物）是抗真菌剂，可用于治疗疾病，包括传染性疾病。本发明提供了治疗受试者疾病（如真菌感染等传染性疾病）的方法，以及杀死或抑制受试者或生物样本中或上的真菌生长的方法。这些化合物可用于受试者、临床环境或农业环境。
• ANTIFUNGAL COMPOUNDS AND USES THEREOF
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20200140381A1

  公开（公告）日：2020-05-07

  Provided herein are compounds (e.g., compounds of Formulae (I), (II), and (III)) which are anti-fungal agents and can be used in the treatment of diseases, including infectious diseases. The invention provides methods of treating diseases in a subject (e.g., infectious diseases such as fungal infections), and methods of killing or inhibiting the growth of fungi in or on a subject or biological sample. The compounds may be used in subjects, in clinical settings, or in agricultural settings.