3,4,3',4'-Tetramethoxy-benzilsaeure-methylester | 110554-10-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4,3',4'-Tetramethoxy-benzilsaeure-methylester
• 英文别名: Bis-(3,4-dimethoxyphenyl)-hydroxyacetic acid, methyl ester；methyl 2,2-bis(3,4-dimethoxyphenyl)-2-hydroxyacetate
• CAS: 110554-10-4
• 化学式: C₁₉H₂₂O₇
• 分子量: 362.379
• InChiKey: KXCZCWAQTLDDCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
  申请人：——

  公开号：US20020119991A1

  公开（公告）日：2002-08-29

  A compound of formula 1 1 wherein: A is a group selected from 2 X − is an anion with a single negative charge; R 1 and R 2 are each independently a C 1 -C 4 -alkyl optionally substituted with hydroxy or halogen; and R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are each independently hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkyloxy, hydroxy, CF 3 , CN, NO 2 , or halogen, with the proviso that at least one of the groups R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 is not hydrogen, processes for preparing these compounds, pharmaceutical compositions containing these compounds, and their use as pharmaceutical compositions.

  化合物的化学式为11，其中：A是从2X−中选择的基团，2X−是带有单负电荷的阴离子；R1和R2各自独立地是C1-C4烷基，可选地被羟基或卤素取代；R3、R4、R5、R6、R7和R8各自独立地是氢、C1-C4烷基、C1-C4烷氧基、羟基、CF3、CN、NO2或卤素，但至少有一个基团R3、R4、R5、R6、R7和R8不是氢。本发明还涉及制备这些化合物的方法、含有这些化合物的药物组合物以及它们作为药物组合物的用途。
• Anticholinergics, processes for preparing them and pharmaceutical composition containing them
  申请人：Meissner Helmut

  公开号：US20050054664A1

  公开（公告）日：2005-03-10

  A compound of formula 1 wherein: A is a group selected from X − is an anion with a single negative charge; R 1 and R 2 are each independently a C 1 -C 4 -alkyl optionally substituted with hydroxy or halogen; and R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are each independently hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkyloxy, hydroxy, CF 3 , CN, NO 2 , or halogen, with the proviso that at least one of the groups R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 is not hydrogen, processes for preparing these compounds, pharmaceutical compositions containing these compounds, and their use as pharmaceutical compositions.

  化合物公式1，其中：A是从X-选择的基团，X-是带有单负电荷的阴离子；R1和R2分别独立地是C1-C4烷基，可选地取代羟基或卤素；而R3、R4、R5、R6、R7和R8分别独立地是氢、C1-C4烷基、C1-C4烷氧基、羟基、CF3、CN、NO2或卤素，但其中至少有一个基团R3、R4、R5、R6、R7或R8不是氢。制备这些化合物的方法，包含这些化合物的制药组合物以及它们作为制药组合物的用途。
• Naphthalene derivative and liquid crystal composition comprising the same
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0952135A1

  公开（公告）日：1999-10-27

  Disclosed is a novel liquid-crystalline compound which is a naphthalene derivative useful as an electro-optical liquid crystal display material, a liquid crystal composition containing such naphthalene derivatives and a liquid crystal display device comprising the same. The naphthalene derivative provided by the present invention exhibits an excellent liquid-crystallinity and miscibility with currently widely used liquid crystal compositions or compositions. The addition of the naphthalene derivative makes it possible to drastically lower the threshold voltage of the liquid crystal composition while maintaining its high response. The naphthalene derivative of the present invention is characterized by a large birefringence index. Further, most of the naphthalene derivative of the present invention has no strongly polar group in its molecule and thus can also be used for active matrix driving. Moreover, as shown in the foregoing examples, the naphthalene derivative of the present invention can be easily produced and is colorless and chemically stable. Accordingly, the liquid crystal composition comprising the naphthalene derivative of the present invention is extremely useful as a practical liquid crystal composition, particularly a liquid crystal composition which can operate within a wide temperature range and requires a high speed response and a low voltage driving.

  本发明公开了一种可用作电光液晶显示材料的新型液晶化合物（一种萘衍生物）、一种含有这种萘衍生物的液晶组合物以及一种包含这种萘衍生物的液晶显示装置。本发明所提供的萘衍生物具有极佳的液晶性，并可与目前广泛使用的液晶组合物或成分混溶。加入萘衍生物后，液晶组合物的阈值电压可大幅降低，同时保持高响应。本发明的萘衍生物具有双折射指数大的特点。此外，本发明的大多数萘衍生物分子中没有强极性基团，因此也可用于活性基质驱动。此外，如上述实例所示，本发明的萘衍生物易于生产，且无色、化学性质稳定。因此，包含本发明萘衍生物的液晶组合物作为实用液晶组合物，特别是作为可在宽温度范围内工作、需要高速响应和低电压驱动的液晶组合物，是非常有用的。
• NEUE ANTICHOLINERGIKA, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL
  申请人：Boehringer Ingelheim Pharma GmbH & Co.KG

  公开号：EP1328524B1

  公开（公告）日：2012-12-12
• US6852728B2
  申请人：——

  公开号：US6852728B2

  公开（公告）日：2005-02-08