2-[(diphenylmethyl)sulfanyl]-N-phenylacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(diphenylmethyl)sulfanyl]-N-phenylacetamide
• 英文别名: 2-benzhydrylsulfanyl-N-phenylacetamide
• 化学式: C₂₁H₁₉NOS
• mdl: MFCD00384514
• 分子量: 333.4
• InChiKey: RUWNLPDUHKOWFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOSITION OF THE TREATMENT OF VASCULAR DISEASES OR KCa3.1 CHANNEL-MEDIATED DISEASES COMPRISING MODAFINIL OR DERIVATIVES THEREOF
  申请人：EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION

  公开号：US20140296333A1

  公开（公告）日：2014-10-02

  The present invention relates to modafinil or derivatives thereof as a medicine for the treatment of vascular diseases or KCa3.1 channel (Ca activated K channel) mediated diseases and a novel use of the same. More specifically, the present invention relates to a pharmaceutical composition for the prevention or treatment of vascular diseases or KCa3.1 channel-mediated diseases comprising modafinil or a derivative of modafinil, or pharmaceutically acceptable salts thereof which relax blood vessels and inhibit KCa3.1 channel currents by increasing intracellular cAMP, a method for treating vascular diseases or KCa3.1 channel-mediated diseases using the composition and a health functional food composition for the prevention or improvement of vascular diseases or the KCa3.1 channel-mediated diseases comprising modafinil or a modafinil derivative compound, or sitologically acceptable salts thereof.

  本发明涉及莫达非尼或其衍生物作为治疗血管疾病或KCa3.1通道（Ca激活的K通道）介导疾病的药物，以及其新的用途。更具体地说，本发明涉及一种用于预防或治疗血管疾病或KCa3.1通道介导疾病的药物组合物，包括莫达非尼或莫达非尼的衍生物，或其药用可接受的盐，通过增加细胞内cAMP来放松血管并抑制KCa3.1通道电流的方法，以及使用该组合物治疗血管疾病或KCa3.1通道介导疾病的方法，以及用于预防或改善血管疾病或KCa3.1通道介导疾病的保健功能食品组合物，包括莫达非尼或莫达非尼衍生物化合物，或其细胞学可接受的盐。
• US9259412B2
  申请人：——

  公开号：US9259412B2

  公开（公告）日：2016-02-16