Benzenesulfonamide, 3,4-dimethoxy-N-(2-cyanoethyl)-

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzenesulfonamide, 3,4-dimethoxy-N-(2-cyanoethyl)-
• 英文别名: N-(2-cyanoethyl)-3,4-dimethoxybenzenesulfonamide
• 化学式: C₁₁H₁₄N₂O₄S
• 分子量: 270.309
• InChiKey: VANKWUOPPVEVOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  96.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-氨基丙腈 、 3,4-二甲氧基苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 Benzenesulfonamide, 3,4-dimethoxy-N-(2-cyanoethyl)-
  参考文献：
  名称：

  Aryl sulfonamides as selective PDE4 inhibitors

  摘要：

  A series of novel selective phosphodiesterase 4 (PDE4) inhibitors has been developed which displays activity both in vitro and in vivo. These compounds possess good selectivity for the catalytic site of PDE4 over the high affinity Rolipram binding site. In vivo studies demonstrate a reduced propensity to display the emetic side effects which are commonly observed with PDE4 inhibitors. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00491-0

文献信息

• Aryl sulfonamides as selective PDE4 inhibitors
  作者：John G Montana、George M Buckley、Nicola Cooper、Hazel J Dyke、Lewis Gowers、Joanna P Gregory、Paul G Hellewell、Hannah J Kendall、Christopher Lowe、Robert Maxey、Jadwiga Miotla、Robert J Naylor、Karen A Runcie、Bishwa Tuladhar、Julie B.H Warneck

  DOI：10.1016/s0960-894x(98)00491-0

  日期：1998.10

  A series of novel selective phosphodiesterase 4 (PDE4) inhibitors has been developed which displays activity both in vitro and in vivo. These compounds possess good selectivity for the catalytic site of PDE4 over the high affinity Rolipram binding site. In vivo studies demonstrate a reduced propensity to display the emetic side effects which are commonly observed with PDE4 inhibitors. (C) 1998 Elsevier Science Ltd. All rights reserved.