3-(3,4-Dichlorophenyl)-1-(5-methyl-2-thiazolin-2-yl)-1-(3,4-xylyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3,4-Dichlorophenyl)-1-(5-methyl-2-thiazolin-2-yl)-1-(3,4-xylyl)urea
• 英文别名: 3-(3,4-dichlorophenyl)-1-(3,4-dimethylphenyl)-1-(5-methyl-4,5-dihydro-1,3-thiazol-2-yl)urea
• 化学式: C₁₉H₁₉Cl₂N₃OS
• 分子量: 408.3
• InChiKey: CJPCBDONPMXCBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• RICTOR-TARGETED THERAPY IN THE MANAGEMENT OF BRAIN METASTASES
  申请人：Albert Einstein College of Medicine

  公开号：US20210205322A1

  公开（公告）日：2021-07-08

  A method of treating metastases (e.g., brain metastases) in a patient with cancer (e.g., lung cancer) and at risk for metastases, exhibiting symptoms of metastases, or identified with metastases includes administering a therapeutically effective amount of a RICTOR inhibitor for the treatment of metastases. A method of reducing resistance to an EGFR, MET or AKT inhibitor in a cancer patient being administered the EGFR. MET or AKT inhibitor comprises co-administering a therapeutically effective amount of a RICTOR inhibitor and the EGFR, MET or AKT inhibitor. RICTOR inhibitors include compounds of formulas I-IV.
• METHODS FOR CELL PROFILING
  申请人：Bailey David Stanley

  公开号：US20210208149A1

  公开（公告）日：2021-07-08

  This invention relates to methods of characterising mammalian cells, e.g. mammalian cancer cells, based on their chemotypic signature. The methods comprise contacting test mammalian cells with a panel of reference compounds, measuring the effect of each reference compound on a phenotypic property of the test mammalian cells to produce a score for each reference compound in the panel, combining the scores to produce a chemotypic signature, and comparing this signature to the signatures of a set of reference mammalian cell lines. This may be useful for diagnostic and prognostic applications, as well as rational drug design, patient stratification, and personalised drug discovery.