2-(3-chloro-2-fluorophenyl)isothiazol-3(2H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-chloro-2-fluorophenyl)isothiazol-3(2H)-one
• 英文别名: 2-(3-chloro-2-fluorophenyl)-1,2-thiazol-3-one
• 化学式: C₉H₅ClFNOS
• 分子量: 229.66
• InChiKey: FLVXYAGCEOJNQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] COMPOSITIONS AND METHODS FOR ENHANCING ENZYME ACTIVITY IN GAUCHER, GM1-GANGLIOSIDOSIS/MORQUIO B DISEASE, AND PARKINSON'S DISEASE<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'AMÉLIORER L'ACTIVITÉ ENZYMATIQUE DANS LA MALADIE DE GAUCHER, LA GANGLIOSIDOSE À GM1, LA MALADIE DE MORQUIO DE TYPE B ET LA MALADIE DE PARKINSON
  申请人：HOSPITAL FOR SICK CHILDREN

  公开号：WO2009049421A1

  公开（公告）日：2009-04-23

  Therapeutic compositions and methods for treatment of lysosomal storage disorders, such as Gaucher, GM1-gangliosidosis/Morquio B disease and Parkinson's disease are described herein. The compositions comprise compounds having glucocerebrosidase and beta-galactosidase inhibitory activity for use as pharmacological chaperones for mutant forms of the enzyme. Methods of treatment involve providing therapeutically effective amounts of such compounds to subjects in need thereof.