5-(triphenyl-λ5-phosphanyl)pentanoic acid;hydrobromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(triphenyl-λ5-phosphanyl)pentanoic acid;hydrobromide
• 化学式: C23H26BrO2P
• 分子量: 445.3
• InChiKey: XYIHKRMCSXPOGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.55
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Internal 1, 15-lactones of fluprostenol and related prostaglandin F2a analogs and their use in the treatment of glaucoma and intraocular hypertension
  申请人：——

  公开号：US20010046982A1

  公开（公告）日：2001-11-29

  Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into ophthalmic solutions and topically applied for the treatment of the increased intraocular pressure caused by glaucoma and the reduction of ocular hypertension.

  PGF系列的前列腺素化合物的新衍生物，特别是fluprostenol和相关的PGF类似物的环状内部1,15-内酯，如cloprostenol或latanoprost。这些新的类似物可以制成眼科溶液，并局部应用于治疗由青光眼引起的眼内压增高和减少眼压。
• 13,14-Dihydro-PGF2BETA and its isopropyl ester
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0628545A1

  公开（公告）日：1994-12-14

  13,14-dihydro-prostaglandin F2β and its isopropyl ester of the formula: reduce intraocular pressure at low concentration and have low stimulus and are therefore useful for preventing and/or treating glaucoma.

  13,14-二氢-前列腺素F2β及其异丙酯酯化物：在低浓度下可降低眼内压力，并具有低刺激性，因此可用于预防和/或治疗青光眼。
• Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds
  申请人：Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo

  公开号：EP0430552A2

  公开（公告）日：1991-06-05

  A use of a 15-ketoprostaglandin compound for the manufacture of a medicament for treatment of a pulmonary dysfunction.

  一种 15-酮前列腺素化合物用于制造治疗肺功能障碍药物的用途。
• Treatment of pancreatic disease with 15-keto-prostaglandin compounds
  申请人：Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo

  公开号：EP0455448A2

  公开（公告）日：1991-11-06

  A use of a 15-ketoprostaglandin compound for the manufacture of a medicament for treatment of a pancreatic disease.

  一种 15-酮前列腺素化合物用于制造治疗胰腺疾病药物的用途。
• Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds
  申请人：Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo

  公开号：EP0430551A2

  公开（公告）日：1991-06-05

  A use of a 15-ketoprostaglandin compound for the manufacture of a medicament for treatment of a cardiac dysfunction.

  一种 15-酮前列腺素化合物用于制造治疗心功能不全的药物。