11-(triphenyl-λ5-phosphanyl)undecanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 11-(triphenyl-λ5-phosphanyl)undecanoic acid
• 化学式: C₂₉H₃₇O₂P
• 分子量: 448.6
• InChiKey: UZCULIRPCSLVBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  32
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PHARMACEUTICAL SUBSTANCES ON THE BASIS OF MITOCHONDRIALLY ADDRESSED ANTIOXIDANTS
  申请人：Obschestvo S Ogranichennoi Otvetstvennostyu "Mitotekh"

  公开号：EP2500336A1

  公开（公告）日：2012-09-19

  This invention relates to the fields of pharmaceutics and medicine, and, in particular, relates to the production and use of pharmaceutical substances on the basis of mitochondria-addressed compounds. The invention discloses methods for synthesis, purification and storage of mitochondria-addressed antioxidants, making it possible to produce said substances in a form and quality meeting the demands made on active ingredients of medicinal preparations - the pharmaceutical substances. The invention also discloses methods for design and selection of new mitochondria-addressed antioxidants having specified properties.

  该发明涉及制药和医学领域，特别是基于线粒体定向化合物的制药物质的生产和使用。该发明揭示了线粒体定向化抗氧化剂的合成、纯化和储存方法，使得能够以符合药物制剂活性成分要求的形式和质量生产这些物质 - 制药物质。该发明还揭示了设计和选择具有特定性质的新线粒体定向化抗氧化剂的方法。
• PHARMACEUTICAL SUBSTANCES ON THE BASIS OF MITOCHONDRIA-ADDRESSED ANTIOXIDANTS
  申请人：Skulachev Maxim V.

  公开号：US20120259110A1

  公开（公告）日：2012-10-11

  This invention relates to the fields of pharmaceutics and medicine, and, in particular, relates to the production and use of pharmaceutical substances on the basis of mitochondria-addressed compounds. The invention discloses methods for synthesis, purification and storage of mitochondria-addressed antioxidants, making it possible to produce said substances in a form and quality meeting the demands made on active ingredients of medicinal preparations—the pharmaceutical substances. The invention also discloses methods for design and selection of new mitochondria-addressed antioxidants having specified properties.

  本发明涉及制药和医学领域，特别是基于线粒体靶向化合物的制药物质的生产和使用。该发明揭示了线粒体靶向抗氧化剂的合成、纯化和储存方法，使得能够以符合药物制剂活性成分要求的形式和质量生产这些物质。该发明还揭示了设计和选择具有指定性质的新线粒体靶向抗氧化剂的方法。
• Pentanedioic acid derivatives
  申请人：G.D. Searle & Co.

  公开号：EP0089674A1

  公开（公告）日：1983-09-28

  Derivates of β-hydroxy-β-alkylglutaric acid are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit β-hydroxy-β-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.

  本文描述了β-羟基-β-烷基戊二酸的衍生物，这些衍生物能够抑制血清胆固醇的形成，因为它们能够抑制血清胆固醇合成过程中的速率控制物质--β-羟基-β-甲基戊二酰-CoA（HMG CoA）。
• NONIMMUNOSUPPRESSIVE CYCLOSPORINE ANALOGUE MOLECULES
  申请人：Hegmans Alexander

  公开号：US20130190223A1

  公开（公告）日：2013-07-25

  The compounds of the present invention are non-immunosupressive cyclosporine analogue molecules that are able to bind cyclophilin. Said compounds include a modified side chain of amino acid I of cyclosporin A, consisting of an oxyalkyl having substituents R′, R1 and R2, where R′ is H or Acetyl; R1 is a saturated or unsaturated straight chain or branched aliphatic carbon chain; and R2 may be a hydrogen; a unsubstituted, N substituted or NN disubstituted amide; a N substituted or unsubstituted acyl protected amine; a carboxylic acid; a N substituted or unsubstituted amine; a nitrile; a ester; a ketone; a hydroxy, dihydroxy, trihydroxy or polyhydroxy alkyl; or a substituted or unsubstituted aryl.
• CYCLOSPORINE ANALOGUE MOLECULES MODIFIED AT AMINO ACID 1 AND 3
  申请人：Hegmans Alexander

  公开号：US20140142033A1

  公开（公告）日：2014-05-22

  Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.