2-((2,6-Dichlorophenyl)amino)benzeneacetaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((2,6-Dichlorophenyl)amino)benzeneacetaldehyde
• 英文别名: 2-[2-(2,6-dichloroanilino)phenyl]acetaldehyde
• 化学式: C₁₄H₁₁Cl₂NO
• 分子量: 280.1
• InChiKey: KOLNXGHWQMEZEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2,6-二氯苯基)-1,3-二氢-2H-吲哚-2-酮 生成 2-((2,6-Dichlorophenyl)amino)benzeneacetaldehyde
  参考文献：
  名称：

  TAKASEH, MUNEHAKI;TAKEHDZAVA, TOSIYUKI;IVASIRO, TAKASI;SUDZUKI, TATEHXIKO+

  摘要：

  DOI：

文献信息

• [EN] NICOTINIC ACID RECEPTOR AGONIST COMPOUNDS USEFUL TO TREAT METABOLIC SYNDROMES<br/>[FR] COMPOSÉS AGONISTES DE RÉCEPTEUR D'ACIDE NICOTINIQUE UTILES POUR TRAITER DES SYNDROMES MÉTABOLIQUES
  申请人：SCHERING CORP

  公开号：WO2010009215A1

  公开（公告）日：2010-01-21

  The present invention provides compounds of the Formula I: (I) wherein R' represents a recoverable residue of a non-steroidal anti-inflammatory drug (NSAID); G represents a hydrolysable or metabolizable linker group; and R represents a recoverable residue of a nicotinic acid receptor agonist; and salts, solvates, esters and prodrugs thereof, as well as pharmaceutical compositions containing them, and methods of using them to treat metabolic syndrome, dyslipidemia, cardiovascular diseases, disorders of the peripheral and central nervous system, hematological diseases, cancer, inflammation, respiratory diseases, gastroenterological diseases, diabetes, and non-alcoholic fatty liver diseases.

  本发明提供了具有以下化学式I的化合物：（I）其中R'代表非甾体抗炎药（NSAID）的可回收残留物；G代表可水解或可代谢的连接基团；R代表烟酸受体激动剂的可回收残留物；以及它们的盐、溶剂合物、酯和前药，以及含有它们的药物组合物，以及使用它们治疗代谢综合征、血脂异常、心血管疾病、周围和中枢神经系统疾病、血液疾病、癌症、炎症、呼吸系统疾病、胃肠疾病、糖尿病和非酒精性脂肪肝病的方法。
• PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF- MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES
  申请人：EMS S. A.

  公开号：EP2418200A1

  公开（公告）日：2012-02-15

  The present invention relates to phthalimide derivatives of non-steroidal and/or TNF-α modulating anti-inflammatory compounds as well as the process of obtaining the so-called derivatives, pharmaceutical compositions containing such derivatives and their uses, including use in the treatment of inflammatory diseases, especially those related to chronic inflammatory processes, such as rheumatoid arthritis and intestinal inflammatory diseases (for instance, Chron's disease) and the use of the referred to pharmaceutical compositions as antipyretic, analgesic and platelet antiaggregating medications.

  本发明涉及非甾体类和/或 TNF-α 调节抗炎化合物的邻苯二甲酰亚胺衍生物，以及获得所谓衍生物的工艺、含有此类衍生物的药物组合物及其用途，包括用于治疗炎症性疾病，尤其是与慢性炎症过程有关的疾病，如类风湿性关节炎和肠道炎症性疾病（如慢性疾病），以及将所述药物组合物用作解热、镇痛和抗血小板聚集药物。
• NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
  申请人：Codexis, Inc.

  公开号：EP3319987B1

  公开（公告）日：2021-05-05
• [EN] SALICYLATE CONJUGATES USEFUL FOR TREATING METABOLIC DISORDERS<br/>[FR] CONJUGUÉS DE SALICYLÉS UTILES POUR LE TRAITEMENT DE TROUBLES MÉTABOLIQUES
  申请人：GENMEDICA THERAPEUTICS SL

  公开号：WO2009138437A1

  公开（公告）日：2009-11-19

  The present invention is directed to methods for treating metabolic disorders with compounds that are salicylate conjugates.