(2R)-2-(methoxycarbonylamino)-3,3-diphenylpropanoic acid | 161869-02-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-2-(methoxycarbonylamino)-3,3-diphenylpropanoic acid
• CAS: 161869-02-9
• 化学式: C₁₇H₁₇NO₄
• 分子量: 299.326
• InChiKey: AZJJNORIBURVFN-OAHLLOKOSA-N

物化性质

• 沸点：
  484.2±45.0 °C(Predicted)
• 密度：
  1.232±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 (2R)-2-(methoxycarbonylamino)-3,3-diphenylpropanoic acid 以 乙醚 为溶剂， 生成 methyl N-methoxycarbonyl-3,3-diphenylpropionate
  参考文献：
  名称：

  Pictet-Spengler Cyclization of 3,3-Diphenylalanine (DIP) (III), Synthesis of Optically Pure 1,2,3,4-Tetrahydro-4-phenyl-3-isoquinolinecarboxylic Acids, Novel α-Amino Acids for Peptides of Biological Interest

  摘要：

  All four isomers of 1,2,3,4-tetrahydro-4-phenyl-3-isoquinolinecarboxylic acid have been synthesized in highoptical purity for the synthesis of peptides of biological interest.

  DOI：

  10.1080/00397919508010788
• 作为产物：
  描述：

  D-diphenylalanine 、 氯甲酸甲酯 在 sodium hydroxide 作用下， 生成 (2R)-2-(methoxycarbonylamino)-3,3-diphenylpropanoic acid
  参考文献：
  名称：

  Pictet-Spengler Cyclization of 3,3-Diphenylalanine (DIP) (III), Synthesis of Optically Pure 1,2,3,4-Tetrahydro-4-phenyl-3-isoquinolinecarboxylic Acids, Novel α-Amino Acids for Peptides of Biological Interest

  摘要：

  All four isomers of 1,2,3,4-tetrahydro-4-phenyl-3-isoquinolinecarboxylic acid have been synthesized in highoptical purity for the synthesis of peptides of biological interest.

  DOI：

  10.1080/00397919508010788

文献信息

• Lysine sulfonamides as novel HIV-protease inhibitors: Nε-Acyl aromatic α-amino acids
  作者：Brent R. Stranix、Jean-François Lavallée、Guy Sévigny、Jocelyn Yelle、Valérie Perron、Nicholas LeBerre、Dominik Herbart、Jinzi J. Wu

  DOI：10.1016/j.bmcl.2006.04.011

  日期：2006.7

  A series of lysine sulfonamide analogues bearing N epsilon-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses. (c) 2006 Elsevier Ltd. All rights reserved.
• Pictet-Spengler Cyclization of 3,3-Diphenylalanine (DIP) (III), Synthesis of Optically Pure 1,2,3,4-Tetrahydro-4-phenyl-3-isoquinolinecarboxylic Acids, Novel α-Amino Acids for Peptides of Biological Interest
  作者：Huai G. Chen、O. P. Goel

  DOI：10.1080/00397919508010788

  日期：1995.1

  All four isomers of 1,2,3,4-tetrahydro-4-phenyl-3-isoquinolinecarboxylic acid have been synthesized in highoptical purity for the synthesis of peptides of biological interest.