1,3-Dioxo-2-[4-(3,4-xylyloxy)phenyl]-5-isoindolinecarboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-Dioxo-2-[4-(3,4-xylyloxy)phenyl]-5-isoindolinecarboxylic acid
• 英文别名: 2-[4-(3,4-dimethylphenoxy)phenyl]-1,3-dioxoisoindole-5-carboxylic acid
• 化学式: C₂₃H₁₇NO₅
• 分子量: 387.4
• InChiKey: BHPAHHGMQRFMGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• KCNQ channels as therapeutic targets
  申请人：Washington University

  公开号：US10064842B2

  公开（公告）日：2018-09-04

  The present disclosure relates to methods and compositions for modulating the activity of KCNQ channels as a means for reducing the effects of aberrant KCNQ channel function associated with epilepsy, deafness and arrhythmias including but not limited to, Long-QT syndrome (“LQTS”), and atrial fibrillation. The present disclosure also relates to the discovery of certain regions of KCNQ channels that interact with various channel stimulating molecules such as, ATP, and PIP2, as well as KCNQ channel domains that effect voltage dependant channel activation. The disclosure is also directed to the use of small molecules to modulate KCNQ channel activity in a cell. Moreover, the present disclosure relates to the therapeutic effects of treating a subject with modulators of KCNQ channel activity.

  本公开涉及调节 KCNQ 通道活性的方法和组合物，以此减少与癫痫、耳聋和心律失常（包括但不限于长 QT 综合征（"LQTS"）和心房颤动）相关的 KCNQ 通道功能异常的影响。本公开内容还涉及发现 KCNQ 通道的某些区域与各种通道刺激分子（如 ATP 和 PIP2）相互作用，以及影响电压依赖性通道激活的 KCNQ 通道结构域。本公开还涉及使用小分子来调节细胞中 KCNQ 通道的活性。此外，本公开还涉及用 KCNQ 通道活性调节剂治疗受试者的治疗效果。
• KCNQ CHANNELS AS THERAPEUTIC TARGETS
  申请人：WASHINGTON UNIVERSITY

  公开号：US20140303226A1

  公开（公告）日：2014-10-09

  The present disclosure relates to methods and compositions for modulating the activity of KCNQ channels as a means for reducing the effects of aberrant KCNQ channel function associated with epilepsy, deafness and arrhythmias including but not limited to, Long-QT syndrome (“LQTS”), and atrial fibrillation. The present disclosure also relates to the discovery of certain regions of KCNQ channels that interact with various channel stimulating molecules such as, ATP, and PIP 2 , as well as KCNQ channel domains that effect voltage dependant channel activation. The disclosure is also directed to the use of small molecules to modulate KCNQ channel activity in a cell. Moreover, the present disclosure relates to the therapeutic effects of treating a subject with modulators of KCNQ channel activity.
• US9345688B2
  申请人：——

  公开号：US9345688B2

  公开（公告）日：2016-05-24