Ophiopogonanone C

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 高异黄酮
• 英文名称: Ophiopogonanone C
• 英文别名: (3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6-methyl-4-oxo-2,3-dihydrochromene-8-carbaldehyde
• 化学式: C₁₉H₁₆O₇
• 分子量: 356.332
• InChiKey: AQUXTCZWTTUERG-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-hydroxy-6-methyl-7-[O-β-D-glucopyranoside]-8-aldehydo-3-(3',4'-methylenedioxybenzyl)chroman-4-one 在 naringinase from P_. decumbens 作用下， 反应 5.0h， 生成 Ophiopogonanone C
  参考文献：
  名称：

  Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity

  摘要：

  Three new homoiso. avonoids (1-3) were isolated from the roots of Ophiopogon japonicus (Liliaceae). The structures of new metabolites were determined on the basis of spectroscopic analyses including 2D NMR. The anti-inflammatory activities of new compounds (1-3) were investigated by their effects on the release of the inflammatory chemokine eotaxin, stimulated by IL-4 and the combination of IL-4 and TNF-alpha in BEAS-2B cells, which mimics the in vivo conditions in bronchial allergic asthma. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.043

文献信息

• Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity
  作者：Tran Manh Hung、Cao Van Thu、Nguyen Tien Dat、Sung-Woo Ryoo、Jeong Hyung Lee、Jin Cheol Kim、Minkyun Na、Hyun-Ju Jung、KiHwan Bae、Byung Sun Min

  DOI：10.1016/j.bmcl.2010.03.043

  日期：2010.4

  Three new homoiso. avonoids (1-3) were isolated from the roots of Ophiopogon japonicus (Liliaceae). The structures of new metabolites were determined on the basis of spectroscopic analyses including 2D NMR. The anti-inflammatory activities of new compounds (1-3) were investigated by their effects on the release of the inflammatory chemokine eotaxin, stimulated by IL-4 and the combination of IL-4 and TNF-alpha in BEAS-2B cells, which mimics the in vivo conditions in bronchial allergic asthma. (C) 2010 Elsevier Ltd. All rights reserved.