(E)-[1-(biphenyl-4-yl)ethylidene]hydrazine | 5758-19-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-[1-(biphenyl-4-yl)ethylidene]hydrazine
• 英文别名: BEH；(E)-1-(4-phenylphenyl)ethylidenehydrazine
• CAS: 5758-19-0
• 化学式: C₁₄H₁₄N₂
• 分子量: 210.279
• InChiKey: HDDXXLBVPQVLQK-LFIBNONCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-乙酰吲哚 、 (E)-[1-(biphenyl-4-yl)ethylidene]hydrazine 以 甲醇 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  联苯乙酮腙-3-乙酰基吲哚西弗碱的制备、结 构和用途

  摘要：

  本发明涉及一种西弗碱化合物的结构、制备方法及部分性质。该化合物外观呈黄色粉末状固体，熔点282.1‑283.8℃，分子式C24H21N3，化学名为：3‑((E)‑((E)‑(1‑联苯‑4‑基)亚乙基)‑肼叉)‑乙基‑1‑H吲哚，结构如下：该化合物制备方法简单，在300‑380nm范围内有强的荧光发射峰。另外，该西弗碱对肺癌细胞A549的IC50(半数抑制浓度)为50.5μM，对乳腺癌细胞4T1的IC50为52.0μM，这表明该化合物对这两种癌细胞具有一定的抑制效果。

  公开号：

  CN107118147B

文献信息

• ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
  申请人：Siga Technologies, Inc.

  公开号：EP1988884A2

  公开（公告）日：2008-11-12
• Antiviral Drugs for Treatment of Arenavirus Infection
  申请人：Hruby Dennis E.

  公开号：US20090036513A1

  公开（公告）日：2009-02-05

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
• US8492434B2
  申请人：——

  公开号：US8492434B2

  公开（公告）日：2013-07-23
• US9199920B2
  申请人：——

  公开号：US9199920B2

  公开（公告）日：2015-12-01
• [EN] ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION<br/>[FR] MEDICAMENTS ANTIVIRAUX POUR LE TRAITEMENT D'INFECTIONS A ARENAVIRUS
  申请人：SIGA TECHNOLOGIES INC

  公开号：WO2007100888A2

  公开（公告）日：2007-09-07

  [EN] Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
  [FR] La présente invention concerne les composés, méthodes et compositions pharmaceutiques pour le traitement d'infections virales par l'administration de certains nouveaux composés en quantités thérapeutiques efficaces. L'invention porte également sur des méthodes de préparation des composés et des méthodes d'utilisation des composés et des compositions pharmaceutiques les contenant. L'invention concerne plus particulièrement le traitement et la prophylaxie d'infections virales telles que celles causées par les virus de la fièvre hémorragique, y compris mais s'en s'y limiter, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe et Pichinde), Filoviridae (virus Ebola et Marburg), Flaviviridae (virus de la fièvre jaune, de la fièvre hémorragique d'Omsk et de la maladie de la forêt de Kyasanur) et enfin Bunyaviridae (fièvre de la vallée du Rift).