2-[(E)-2-(4-methylphenyl)sulfonylethenyl]-5-nitrofuran | 81191-20-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(E)-2-(4-methylphenyl)sulfonylethenyl]-5-nitrofuran
• CAS: 81191-20-0
• 化学式: C13H11NO5S
• 分子量: 293.3
• InChiKey: PGRCPHNRPHKODQ-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• METHODS, PHARMACEUTICAL COMPOSITIONS, THERAPEUTIC SYSTEMS, AND COMPOUNDS FOR TREATING B CELL MALIGNANCIES
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150010643A1

  公开（公告）日：2015-01-08

  This invention relates to a method of treating B cell malignancies, which involves administering to a subject a compound having a structure of formula (I) to cause cell death of a B cell malignancy, thereby treating the B cell malignancy in the subject. Also disclosed are a method of causing cell death of malignant B cells, pharmaceutical compositions and therapeutic systems comprising a compound having a structure of formula (I), and a compound having a structure of formula (I).
• US9458123B2
  申请人：——

  公开号：US9458123B2

  公开（公告）日：2016-10-04
• [EN] METHODS, PHARMACEUTICAL COMPOSITIONS, THERAPEUTIC SYSTEMS, AND COMPOUNDS FOR TREATING B CELL MALIGNANCIES<br/>[FR] PROCÉDÉS, COMPOSITIONS PHARMACEUTIQUE, SYSTÈMES THÉRAPEUTIQUES ET COMPOSÉS POUR LE TRAITEMENT DE MALIGNITÉS LYMPHOCYTAIRES À CELLULES B
  申请人：UNIV ROCHESTER

  公开号：WO2013123320A1

  公开（公告）日：2013-08-22

  This invention relates to a method of treating B cell malignancies, which involves administering to a subject a compound having a structure of formula (I) to cause cell death of a B cell malignancy, thereby treating the B cell malignancy in the subject. Also disclosed are a method of causing cell death of malignant B cells, pharmaceutical compositions and therapeutic systems comprising a compound having a structure of formula (I), and a compound having a structure of formula (I).