(E)-4-[(2-methoxycarbonyl-5-thiophen-2-ylthiophen-3-yl)amino]-4-oxobut-2-enoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: (E)-4-[(2-methoxycarbonyl-5-thiophen-2-ylthiophen-3-yl)amino]-4-oxobut-2-enoic acid
• 化学式: C₁₄H₁₁NO₅S₂
• 分子量: 337.4
• InChiKey: GJODSFZNKNHKML-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  149
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• TARGETING LIPID METABOLISM AND FREE FATTY ACID (FFA) OXIDATION TO TREAT DISEASES MEDIATED BY RESIDENT MEMORY T CELLS (TRM)
  申请人：The Brigham & Women's Hospital, Inc.

  公开号：EP3755322A1

  公开（公告）日：2020-12-30
• COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING CANCER BY INHIBITING FATTY ACID BINDING PROTEINS
  申请人：Lengyel Ernst

  公开号：US20120289570A1

  公开（公告）日：2012-11-15

  The present invention concerns methods and compositions for the inhibition or reduction of the primary tumor and metastasis by inhibition of fatty acid binding proteins.
• Compositions and Methods for Treating and/or Preventing Cancer by Inhibiting Fatty Acid Binding Proteins
  申请人：The University of Chicago

  公开号：US20140363522A1

  公开（公告）日：2014-12-11

  The present invention concerns methods and compositions for the inhibition or reduction of the primary tumor and metastasis by inhibition of fatty acid binding proteins.
• Targeting Lipid Metabolism and Free Fatty Acid (FFA) Oxidation to Treat Diseases Mediated by Resident Memory T Cells (TRM)
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US20200375965A1

  公开（公告）日：2020-12-03

  Methods for treating, or reducing risk of development or progression of, a tissue-resident memory T cells (TRM)-mediated disease, comprising administering a therapeutically effective amount of one or more inhibitors of exogenous lipid and free fatty acid uptake or of mitochondrial beta oxidation of internalized exogenous FFA (e.g., inhibitors of CD36 and/or FABP antagonists, e.g., inhibitors of FABP4 and/or FABP5, and/or CPT1) to a subject in need thereof.
• US8748470B2
  申请人：——

  公开号：US8748470B2

  公开（公告）日：2014-06-10