1-tert-butyl-4-fluoro-2-nitro-benzene | 610-18-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-tert-butyl-4-fluoro-2-nitro-benzene
• 英文别名: 1-tert-Butyl-4-fluor-2-nitro-benzol；1-Tert-butyl-4-fluoro-2-nitrobenzene；1-tert-butyl-4-fluoro-2-nitrobenzene
• CAS: 610-18-4
• 化学式: C₁₀H₁₂FNO₂
• 分子量: 197.209
• InChiKey: CYRBVKBJKJMNLE-UHFFFAOYSA-N

物化性质

• 沸点：
  90-92 °C(Press: 7 Torr)
• 密度：
  1.145±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 1-tert-butyl-4-fluoro-2-nitro-benzene
  参考文献：
  名称：

  Bevan et al., Journal of the Chemical Society, 1956, p. 4284,4286

  摘要：

  DOI：

文献信息

• Luciferin Derivatives from Bicyclic Reactants and Aminothiol Derivatives and Methods of Use Thereof
  申请人：The Regents of the University of California

  公开号：US20130287699A1

  公开（公告）日：2013-10-31

  The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.

  本公开涉及一种可以在生理条件下进行的缩合反应和发光素暴露反应。通常，缩合反应涉及将双环反应物与氨基硫醇衍生物反应，生成发光素或发光素衍生物。发光素可以提供可检测的发光。发光素衍生物可以在发光素暴露反应中被揭示出来，提供可检测的发光。本公开提供适用于缩合反应的双环反应物和氨基硫醇衍生物。缩合和发光素暴露反应在各种应用中有用，这些应用也被提供。
• LUCIFERIN DERIVATIVES FROM BICYCLIC REACTANTS AND AMINOTHIOL DERIVATIVES AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：US20160015835A1

  公开（公告）日：2016-01-21

  The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.

  本公开涉及一种可以在生理条件下进行的缩合反应和发光素解掩蔽反应。一般而言，缩合反应涉及将双环反应物与氨硫醇衍生物反应，生成发光素或发光素衍生物。发光素可以提供可检测的发光。发光素衍生物可以在发光素解掩蔽反应中被揭示出来，提供可检测的发光。本公开提供了适用于缩合反应的双环反应物和氨硫醇衍生物。缩合和发光素解掩蔽反应在多种应用中发挥作用，这些应用也被提供。
• US9173966B2
  申请人：——

  公开号：US9173966B2

  公开（公告）日：2015-11-03