N-[(5-bromo-2-hydroxyphenyl)methylideneamino]pyridine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-[(5-bromo-2-hydroxyphenyl)methylideneamino]pyridine-2-carboxamide
• 化学式: C₁₃H₁₀BrN₃O₂
• mdl: MFCD02343926
• 分子量: 320.14
• InChiKey: VMUOWOFNRPSKQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• ANTIMICROBIAL PYRIDINOHYDRAZIDE AND HYDRAZOMETHYLPYRIDINE-BASED AGENTS
  申请人：Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

  公开号：US20180072675A1

  公开（公告）日：2018-03-15

  A class of modified salicylaldehyde derivatives has also been synthesized and a series of modified pyridine-based hydrazones identified that have potent antimicrobial activity against multiple Candida spp. These compounds have been characterized using fungal growth inhibition assays, mammalian cell toxicity assays, time-kill assays and synergy studies of these novel pyridine-based hydrazones on both azole-susceptible and azole-resistant fungal species. Effectiveness of these compounds in inhibiting the growth of protozoal parasites was also found.
• [EN] ANTIMICROBIAL PYRIDINOHYDRAZIDE AND HYDRAZOMETHYLPYRIDINE-BASED AGENTS<br/>[FR] AGENTS ANTIMICROBIENS À BASE DE PYRIDINOHYDRAZIDE ET D'HYDRAZOMÉTHYLPYRIDINE
  申请人：UNIV LOUISIANA STATE

  公开号：WO2016160552A1

  公开（公告）日：2016-10-06

  A class of modified salicylaldehyde derivatives has also been synthesized and a series of modified pyridine-based hydrazones identified that have potent antimicrobial activity against multiple Candida spp. These compounds have been characterized using fungal growth inhibition assays, mammalian cell toxicity assays, time-kill assays and synergy studies of these novel pyridine-based hydrazones on both azole-susceptible and azole- resistant fungal species. Effectiveness of these compounds in inhibiting the growth of protozoal parasites was also found.