N-(3-Methyl-4-chlorphenyl)-phenylthioacetamid | 24043-23-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-Methyl-4-chlorphenyl)-phenylthioacetamid
• 英文别名: N-(4-chloro-3-methylphenyl)-2-(phenylsulfanyl)acetamide；N-(4-chloro-3-methylphenyl)-2-phenylsulfanylacetamide
• CAS: 24043-23-0
• 化学式: C₁₅H₁₄ClNOS
• 分子量: 291.801
• InChiKey: QUERUSBVQLFYFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE ACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14
  申请人：THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE

  公开号：US20160146784A1

  公开（公告）日：2016-05-26

  The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.
• US9238034B2
  申请人：——

  公开号：US9238034B2

  公开（公告）日：2016-01-19
• US9797882B2
  申请人：——

  公开号：US9797882B2

  公开（公告）日：2017-10-24