申请人:Doyle Kevin James
公开号:US20100144733A1
公开(公告)日:2010-06-10
The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
本发明涉及用于治疗动物体内对抑制功能性囊性纤维化跨膜传导调节因子(CFTR)多肽敏感的疾病的组合物和方法,通过向需要治疗该疾病的哺乳动物中投与本文所定义的化合物的有效量(包括表1-14中列出的化合物或公式I-XII所包含的化合物)或其组合物,从而治疗该疾病。本发明特别涉及治疗腹泻和多囊肾病的方法。