(2R)-2-[(3-methyl-4-nitrophenoxy)methyl]oxirane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-2-[(3-methyl-4-nitrophenoxy)methyl]oxirane
• 化学式: C₁₀H₁₁NO₄
• mdl: MFCD00454174
• 分子量: 209.202
• InChiKey: KPSRPFWGKNZDPP-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  67.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-硝基间甲苯酚 、 环氧溴丙烷 在 chiral polymer-supported Co(salen) complex 高氟叔丁醇 、 氢氧化钾 作用下， 以 二氯甲烷 、 乙醚 为溶剂， 反应 9.0h， 生成 (S)-glycidyl 3-methyl-4-nitrophenyl ether 、 (2R)-2-[(3-methyl-4-nitrophenoxy)methyl]oxirane
  参考文献：
  名称：

  Enantioselective Parallel Synthesis Using Polymer-Supported Chiral Co(salen) Complexes

  摘要：

  [GRAPHICS]The kinetic resolution of epoxides with phenols catalyzed by a polymer supported Co(salen) complex is applied to the first enantioselective catalytic synthesis of parallel libraries, The corresponding 1-aryloxy-2-alcohols are obtained in high yield, purity, and enantiomeric excess. Further elaboration with diversity elements provides highly efficient access to important classes of pharmacologically active compounds.

  DOI：

  10.1021/ol990920q

文献信息

• Enantioselective Parallel Synthesis Using Polymer-Supported Chiral Co(salen) Complexes
  作者：Stefan Peukert、Eric N. Jacobsen

  DOI：10.1021/ol990920q

  日期：1999.10.1

  [GRAPHICS]The kinetic resolution of epoxides with phenols catalyzed by a polymer supported Co(salen) complex is applied to the first enantioselective catalytic synthesis of parallel libraries, The corresponding 1-aryloxy-2-alcohols are obtained in high yield, purity, and enantiomeric excess. Further elaboration with diversity elements provides highly efficient access to important classes of pharmacologically active compounds.