4-(2,5-Dimethylphenyl)sulfonylmorpholine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,5-Dimethylphenyl)sulfonylmorpholine
• 化学式: C₁₂H₁₇NO₃S
• mdl: MFCD00811819
• 分子量: 255.34
• InChiKey: LJSBGGIQWUCTIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• FARNESOID X RECEPTOR ANTAGONISTS
  申请人：City of Hope

  公开号：US20200290974A1

  公开（公告）日：2020-09-17

  Provided herein are Farnesoid X receptor (FXR) antagonists having the structure of formula (I), and pharmaceutical compositions comprising the compound of formula (I) and a pharmaceutically acceptable excipient. Also provided are methods of antagonizing FXR, and methods of treating metabolic disease in a subject in need thereof, comprising administering an effective amount of the FXR antagonists of formula (I) to a subject.