4-[(3,4-Dimethylphenyl)sulfonyl]morpholine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(3,4-Dimethylphenyl)sulfonyl]morpholine
• 英文别名: 4-(3,4-dimethylphenyl)sulfonylmorpholine
• 化学式: C₁₂H₁₇NO₃S
• mdl: MFCD01116087
• 分子量: 255.34
• InChiKey: JNGAHXBCARGAQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] 2-SUBSTITUTED AMINO-NAPHTH[1,2-D]IMIDAZOL-5-ONE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF CROSS REFERENCE TO RELATED APPLICATIONS<br/>[FR] COMPOSÉS AMINO-NAPHTH [1,2-D] IMIDAZOL-5-ONE SUBSTITUÉS EN POSITION 2 OU LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES
  申请人：BIOELECTRON TECH CORP

  公开号：WO2018093957A1

  公开（公告）日：2018-05-24

  Provided herein are therapeutic and/or prophylactic compounds for mitochondrial or oxidative stress diseases such as cancer, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, Machado-Joseph disease, spinocerebellar ataxia, Huntington disease, Parkinson disease, Alzheimer disease, myocardial infarction, cerebral infarction, diseases related to aging, diabetes, alcoholic liver injury, chronic obstructive pulmonary disease, mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and the like, wherein the compound is represented by formula (1), or reduced forms thereof, or pharmaceutically acceptable salts thereof.

  本文提供了治疗和/或预防线粒体或氧化应激疾病的化合物，如癌症、肌萎缩性侧索硬化症、克雅氏病、马查多-约瑟夫病、脊髓小脑性共济失调、亨廷顿病、帕金森病、阿尔茨海默病、心肌梗死、脑梗死、与衰老相关的疾病、糖尿病、酒精性肝损伤、慢性阻塞性肺疾病、线粒体肌病、脑病、乳酸中毒和类似中风的发作（MELAS）等，其中该化合物由式（1）或其还原形式或其药学上可接受的盐所代表。
• Aryl substituted imidazonaphthyridines
  申请人：Niwas Shri

  公开号：US20070219228A1

  公开（公告）日：2007-09-20

  Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

  本发明公开了以芳基取代的咪唑萘啉环系统化合物、含有该化合物的制药组合物，以及将这些化合物用作免疫调节剂的方法，用于在动物体内诱导细胞因子的生物合成，并用于治疗包括病毒性和肿瘤性疾病在内的疾病。
• 4-PYRIDINYL FORMAMIDE COMPOUND OR DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, HERBICIDAL COMPOSITION AND USE THEREOF
  申请人：Qingdao KingAgroot Chemical Compound Co., Ltd.

  公开号：EP3892618A1

  公开（公告）日：2021-10-13

  The invention belongs to the technical field of pesticides, and specifically relates to a 4-pyridinyl formamide compound or a derivative thereof, a preparation method therefor, a herbicidal composition and the use thereof. The 4-pyridinyl formamide compound is as represented by formula (I), wherein, X and Y each independently represent nitro, halogen, cyano, formyl, thiocyano, mercapto, etc.; and M represents an unsubstituted or substituted structure (II). The compound, and the derivative and the composition thereof have excellent herbicidal activity and a higher crop safety, and establish good selectivity, especially for key crops such as wheat and rice.

  本发明属于农药技术领域，具体涉及一种4-吡啶基甲酰胺化合物或其衍生物、其制备方法、除草组合物及其用途。4-吡啶基甲酰胺化合物由式（I）表示，其中，X 和 Y 各自独立地代表硝基、卤素、氰基、甲酰基、硫氰基、巯基等；M 代表未取代或取代的结构（II）。该化合物及其衍生物和组合物具有优异的除草活性和更高的作物安全性，并建立了良好的选择性，尤其适用于小麦和水稻等主要作物。
• 2-substituted amino-naphth (1,2-d) imidazol-5-one compounds or pharmaceutically acceptable salts thereof
  申请人：PTC THERAPEUTICS, INC.

  公开号：US10738014B2

  公开（公告）日：2020-08-11

  Provided herein are therapeutic and/or prophylactic compounds for mitochondrial or oxidative stress diseases such as cancer, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, Machado-Joseph disease, spinocerebellar ataxia, Huntington disease, Parkinson disease, Alzheimer disease, myocardial infarction, cerebral infarction, diseases related to aging, diabetes, alcoholic liver injury, chronic obstructive pulmonary disease, mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and the like, wherein the compound is represented by formula (1), or reduced forms thereof, or pharmaceutically acceptable salts thereof.

  本文提供了治疗和/或预防线粒体或氧化应激疾病的化合物，如癌症、肌萎缩侧索硬化症、克雅氏病、马查多-约瑟夫病、脊髓小脑共济失调、亨廷顿病、帕金森病、阿尔茨海默病、心肌梗塞、脑梗塞、与衰老有关的疾病、糖尿病、酒精性肝损伤、慢性阻塞性肺病、线粒体肌病、脑病、乳酸酸中毒和中风样发作（MELAS）等，其中化合物由式（1）表示，或其还原型，或其药学上可接受的盐。
• 2-SUBSTITUTED AMINO-NAPHTH[1,2-D]IMIDAZOL-5-ONE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
  申请人：PTC Therapeutics, Inc.

  公开号：EP3541814B1

  公开（公告）日：2021-10-20