1-[(4-fluorophenyl)sulfonyl]-2-methyl-1H-benzimidazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(4-fluorophenyl)sulfonyl]-2-methyl-1H-benzimidazole
• 英文别名: 1-(4-fluorophenyl)sulfonyl-2-methylbenzimidazole
• 化学式: C₁₄H₁₁FN₂O₂S
• 分子量: 290.31
• InChiKey: SMGZHCSEIBBFEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• FLUORESCENT PROBE FOR ALDH3A1 DETECTION
  申请人：The University of Tokyo

  公开号：US20200207989A1

  公开（公告）日：2020-07-02

  [Problem to be Solved] To provide a fluorescent probe for ALDH3A1 detection that can be used in flow cytometry adaptable to live cells. [Means of Resolution] A compound represented by general formula (I) or a salt thereof, wherein the compound or salt thereof has a retention time on an HPLC chromatogram measured under the following conditions of longer than 6.9 minutes when said compound is in aldehyde form and of 6.9 minutes or less when said compound is in carboxylic acid form.

  [问题解决方法] 提供一种适用于流式细胞术的ALDH3A1检测的荧光探针，可适用于活细胞。 [解决方法] 一种由通用式(I)表示的化合物或其盐，其中当所述化合物为醛形式时，在以下条件下测得的HPLC色谱图上的保留时间长于6.9分钟，当所述化合物为羧酸形式时，保留时间为6.9分钟或更短。
• NOVEL REGULATORS OF ALDEHYDE DEHYDROGENASE ALDH3A1 AND RELATED THERAPEUTIC METHODS
  申请人：Indiana University Research and Technology Corporation

  公开号：US20150202169A1

  公开（公告）日：2015-07-23

  Described herein are compositions and methods for the treatment of cancer, and in particular cancers characterized by a high level of ALD3H1 activity, which is associated with chemoresistance to cancer chemotherapeutic agents that are degraded by ALD3H1. The compositions described herein act as competitive inhibitors of ALD3H1 and thereby reduce breakdown of chemotherapeutics by this enzyme, and increase their efficacy for cancer treatment.
• US9320722B2
  申请人：——

  公开号：US9320722B2

  公开（公告）日：2016-04-26