N-benzyl-N-methyl-1-propan-2-ylpiperidin-4-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-methyl-1-propan-2-ylpiperidin-4-amine
• 化学式: C₁₆H₂₆N₂
• 分子量: 246.39
• InChiKey: DMNFRUBLQLMLAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel gamma secretase inhibitors
  申请人：Schering-Plough Corporation

  公开号：US20040171614A1

  公开（公告）日：2004-09-02

  This invention discloses novel gamma secretase inhibitors of the formula: 1 wherein: R 1 is a substituted aryl or substituted heteroaryl group; R 2 is an R 1 group, alkyl, —XC(O)Y, alkylene-XC(O)Y, cycloalkylene-X-C(O)—Y, —CH—X—C(O)—NR 3 —Y or —CH—X—C(O)—Y, wherein X and Y are as defined herein; each R 3 and each R 3A are independently H, or alkyl; R 11 is aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. Also disclosed is a method of treating Alzheimer's Disease using one or more compounds of the invention.

  这项发明揭示了一种新颖的伽玛分泌酶抑制剂，其化学式为：其中：R1为取代芳基或取代杂芳基；R2为R1基团、烷基、—XC(O)Y、烷基烯-XC(O)Y、环烷基烯-X-C(O)—Y、—CH—X—C(O)—NR3—Y或—CH—X—C(O)—Y，其中X和Y如本文中所定义；每个R3和每个R3A独立地为H或烷基；R11为芳基、杂芳基、烷基、环烷基、芳基烷基、芳基环烷基、杂芳基烷基、杂芳基环烷基、芳基杂环烷基或烷氧基烷基。还公开了使用该发明的一个或多个化合物治疗阿尔茨海默病的方法。
• Toll-like receptor antagonist compounds and methods of use
  申请人：Dynavax Technologies Corporation

  公开号：US11370794B2

  公开（公告）日：2022-06-28

  The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I), and pharmaceutical compositions thereof, are antagonists of toll-like receptors such as TLR7, TLR8, and/or TLR9. In certain embodiments, compounds of the invention are useful for inhibiting immune response and treating diseases associated with undesirable immune response.

  本发明涉及式 (I) 化合物： 或其盐或溶液，其中变量如本文所述。式（I）化合物及其药物组合物是类毒素受体如 TLR7、TLR8 和/或 TLR9 的拮抗剂。在某些实施方案中，本发明的化合物可用于抑制免疫反应和治疗与不良免疫反应相关的疾病。
• TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE
  申请人：Dynavax Technologies Corporation

  公开号：US20190345161A1

  公开（公告）日：2019-11-14

  The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.
• US7208602B2
  申请人：——

  公开号：US7208602B2

  公开（公告）日：2007-04-24
• US7256186B2
  申请人：——

  公开号：US7256186B2

  公开（公告）日：2007-08-14