1-(3-Iodobenzoyl)-4-methylpiperidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-Iodobenzoyl)-4-methylpiperidine
• 英文别名: (3-iodophenyl)-(4-methylpiperidin-1-yl)methanone
• 化学式: C₁₃H₁₆INO
• mdl: MFCD02575600
• 分子量: 329.18
• InChiKey: CTABXYOMYAWEJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS
  申请人：YAMASHITA Hiroshi

  公开号：US20120028920A1

  公开（公告）日：2012-02-02

  A heterocyclic compound or a salt thereof represented by the formula (1): where R 2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R 1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.

  一种由式（1）所表示的杂环化合物或其盐：其中R2代表氢原子或较低的烷基基团；A代表较低的烷基烯基基团；R1代表芳香基团或杂环基团。本发明的化合物具有广泛的治疗精神障碍的光谱，包括中枢神经系统障碍，无副作用且安全性高。
• USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1732534A1

  公开（公告）日：2006-12-20
• [EN] USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS<br/>[FR] UTILISANT DE DERIVES DE METHYLENE AMIDE EN CAS DE TROUBLES CARDIO-VASCULAIRES
  申请人：APLLIED RES SYSTEMS ARS HOLDIN

  公开号：WO2005082347A1

  公开（公告）日：2005-09-09

  The present invention is related to the use of substituted methylene amide derivatives of Formula (I) for the treatment and/or prevention of cardiovascular disorders such as coronary obstruction and heart failure. In particular, the present invention is related to the use of substituted methylene amide derivatives of Formula (I) in particular for the treatment and/or prevention of endothelial dysfunction in heart failure.