1-Methyl-2-brom-pyridinium | 52725-12-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Methyl-2-brom-pyridinium
• 英文别名: 2-Bromo-1-methylpyridinium；2-bromo-1-methylpyridin-1-ium
• CAS: 52725-12-9
• 化学式: C₆H₇BrN
• 分子量: 173.032
• InChiKey: ZUHZWFGTRURCNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-Methyl-2-brom-pyridinium 在 sodium azide 作用下， 以 水 为溶剂， 生成 2-Azido-1-methyl-pyridinium
  参考文献：
  名称：

  Abnormal micellar effects on reactions of azide and N-alkyl-2-bromopyridinium ions

  摘要：

  DOI：

  10.1021/jo00381a032

文献信息

• Process for the preparation of esters
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04206310A1

  公开（公告）日：1980-06-03

  An improved process for producing an ester from a carboxylic acid and an alcohol which comprises reacting said carboxylic acid with said alcohol by the use of a 1-substituted-2-halopyridinium salt or a 1-substituted-2-haloquinolinium salt as a condensing agent in the presence of a hydrogen halide captor. According to this process, various esters, even if they have some steric hindrances, may be obtained in good yields.

  一种改进的制备酯的方法，包括在氢卤酸捕获剂的存在下，使用1-取代-2-卤代吡啶盐或1-取代-2-卤代喹啉盐作为缩合剂，通过将所述羧酸与所述醇反应来制备所述酯。根据这种方法，即使酯具有一些立体障碍，也可以获得良好的产率。
• Novel vitamin E derivatives and process for the production thereof
  申请人：Eisai Co., Ltd.

  公开号：EP0436911A2

  公开（公告）日：1991-07-17

  The novel vitamin E derivative provides an excellent antihyperlipemic effect and is defined by the formula (I): wherein R represents a nicotinoyl group; and m is an integer of from 2 to 5 while n is an integer of from 3 to 6, provided that n is larger than m

  新型维生素 E 衍生物具有极佳的抗高血脂作用，其定义见式 (I)： 其中 R 代表烟酰基；m 为 2 至 5 的整数，n 为 3 至 6 的整数，条件是 n 大于 m
• Novel silicon containing alpha-cyanoacrylates
  申请人：THREE BOND CO., LTD.

  公开号：EP0459617A1

  公开（公告）日：1991-12-04

  Novel silicon containing α-cyanoacrylates represented by the general formula I wherein R¹ is an alkylene group having 1 to 6 carbon atoms, and R², R³ and R⁴ are each an alkyl group having 1 to 6 carbon atoms may be prepared by dehydrococondensing a cyanoacetate of the general formula II and formaldenyde or paraformaldehyde The silicon containing α-cyanoacrylates obtained are useful as adhesives.

  通式 I 所代表的新型含硅α-氰基丙烯酸酯 其中 R¹ 为具有 1 至 6 个碳原子的亚烷基，R²、R³ 和 R⁴ 各为具有 1 至 6 个碳原子的烷基，可通过将通式 II 的氰基乙酸酯与甲醛或多聚甲醛脱氢缩合来制备 得到的含硅α-氰基丙烯酸酯可用作粘合剂。
• METHOD FOR PRODUCING HAIRPIN SINGLE-STRAND RNA MOLECULES
  申请人：Toray Industries, Inc.

  公开号：EP3862431A1

  公开（公告）日：2021-08-11

  The present invention relates to a method for producing a hairpin single-stranded RNA molecule capable of inhibiting expression of a target gene, comprising the step of reacting a first single-stranded oligo-RNA molecule represented by the following formula (I) with a second single-stranded oligo-RNA molecule represented by the following formula (II) in a mixed solvent comprising a buffer solution and a hydrophilic organic solvent in the presence of a dehydration condensation agent: 5'-Xc-Lx1 ... (I) and Lx2-X-Y-Ly-Yc-3' ... (II), wherein the dehydration condensation agent is selected from the group consisting of a triazine-based dehydration condensation agent, a uronium-based dehydration condensation agent comprising an N-hydroxy nitrogen-containing aromatic ring structure, a carbodiimide-based dehydration condensation agent, a 2-halopyridinium-based dehydration condensation agent, and a formamidinium-based dehydration condensation agent.

  本发明涉及一种生产能够抑制靶基因表达的发夹型单链 RNA 分子的方法，包括以下步骤： 在由缓冲溶液和亲水性有机溶剂组成的混合溶剂中，在脱水缩合剂存在的情况下，由下式 (I) 表示的第一单链寡核苷酸分子与由下式 (II) 表示的第二单链寡核苷酸分子反应： 5'-Xc-Lx1 ...... (I) 和 Lx2-X-Y-Ly-Yc-3' ...... (II) ，其中脱水缩合剂选自由三嗪类脱水缩合剂、脲类脱水缩合剂、脲类脱水缩合剂和脲类脱水缩合剂组成的组。...(I)和 Lx2-X-Y-Ly-Yc-3' ...(II)，其中脱水缩合剂选自由三嗪基脱水缩合剂、包含 N-羟基含氮芳香环结构的脲基脱水缩合剂、碳二亚胺基脱水缩合剂、2-卤代吡啶鎓基脱水缩合剂和甲脒基脱水缩合剂组成的组。
• BIODEGRADABLE POLYMER, PRODUCTION METHOD THEREOF, MOLDED PRODUCT THEREOF, AND USE THEREOF
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1897901B1

  公开（公告）日：2015-03-11