5-(Methylthio)nicotinic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(Methylthio)nicotinic acid
• 英文别名: 5-methylsulfanylpyridine-3-carboxylic acid
• 化学式: C₇H₇NO₂S
• mdl: MFCD01860194
• 分子量: 169.2
• InChiKey: FQCSMNSGVUHKKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  75.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Combination therapy using a chemokine receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor
  申请人：CHEMOCENTRYX, INC.

  公开号：US11304952B2

  公开（公告）日：2022-04-19

  The present disclosure is drawn to the combination therapy of a Chemokine Receptor 2 (CCR2) antagonist and a PD-1 and/or PD-L1 inhibitor in the treatment of cancer.

  本公开涉及化合因子受体 2 (CCR2) 拮抗剂与 PD-1 和/或 PD-L1 抑制剂在治疗癌症方面的联合疗法。
• COMBINATION THERAPY USING A CHEMOKINE RECEPTOR 2 (CCR2) ANTAGONIST AND A PD-1/PD-L1 INHIBITOR
  申请人：CHEMOCENTRYX, INC.

  公开号：US20190134049A1

  公开（公告）日：2019-05-09

  The present disclosure is drawn to the combination therapy of a Chemokine Receptor 2 (CCR2) antagonist and a PD-1 and/or PD-L1 inhibitor in the treatment of cancer.
• SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20200121688A1

  公开（公告）日：2020-04-23

  Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.