N-(2-carbamoylphenyl)-3,4-dimethoxybenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-carbamoylphenyl)-3,4-dimethoxybenzamide
• 化学式: C₁₆H₁₆N₂O₄
• 分子量: 300.31
• InChiKey: QCSOLXKEFBSDLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  90.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 2-ACYLAMINOBENZAMIDE DERIVATIVES AND PREVENTIVE AND REMEDY FOR DISEASES CAUSED BY THE SUPERMULTIPLICATION OF VASCULAR INTIMAL CELLS
  申请人：KISSEI PHARMACEUTICAL CO., LTD.

  公开号：EP0855387A1

  公开（公告）日：1998-07-29

  The present invention relates to 2-acylaminobenzamide derivatives represented by the general formula: wherein R1, R2, R3, R4 and R5 represent each a hydrogen atom etc.; X represents a vinylene group etc.; B represents a group represented by the general formula:         -N(R6)(R7) wherein R6 and R7 represent each a hydrogen atom etc., a group represented by the general formula:         -NH-(CH2)n-A-R8 wherein A represents a single bond etc.; R8 represents a hydroxy group etc. or a hydroxyamino group which are useful as agents for the prevention and treatment of diseases caused by excessive proliferation of vascular intimal cells.

  本发明涉及由通式表示的 2-酰氨基苯甲酰胺衍生物： 其中R1、R2、R3、R4和R5分别代表氢原子等；X代表乙烯基等；B代表通式所代表的基团： -N(R6)(R7) 其中 R6 和 R7 各自代表一个氢原子等；B 代表由通式表示的基团： -NH-(CH2)n-A-R8 其中 A 代表单键等；R8 代表羟基等或羟基氨基，它们可用作预防和治疗因血管内膜细胞过度增殖而引起的疾病的药物。
• US6103729A
  申请人：——

  公开号：US6103729A

  公开（公告）日：2000-08-15
• [EN] CATHECOL DERIVATIVES AND A METHOD FOR THE PREPARATION THEREOF AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME<br/>[FR] DERIVES DE CATECHOL, LEUR PROCEDE DE PREPARATION ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
  申请人：CHEIL JEDANG CORPORATION

  公开号：WO1998023620A1

  公开（公告）日：1998-06-04

  (EN) A phosphodiesterase IV inhibiting cathecol derivatives of general formula (I) or a pharmaceutically acceptable salt thereof, in which R1 is C1-7 alkyl; C3-7 cycloalkane; phenyl optionally substituted with lower alkyl, lower alkoxy, nitro or halogen; pyrimidine optionally substituted with lower alkyl, lower alkoxy, nitro or halogen; or pyridine optionally substituted with lower alkyl, lower alkoxy, nitro or halogen; X, Y and Z are each independently oxygen, nitrogen or sulfur optionally substituted with C1-7 alkyl, C3-7 cycloalkane or phenyl; W is oxygen or sulfur is disclosed. In addition, a process for producing the compound of general formula (I) and a pharmaceutical composition containing pharmaceutically effective amount of the compound of general formula (I) are disclosed.(FR) L'invention concerne des dérivés de catéchol inhibant la phosphodiestérase IV, de formule générale (I), ou bien un sel pharmaceutiquement acceptable de ceux-ci, formule dans laquelle R1 représente alkyle C1-7; cycloalcane C3-7; phényle facultativement substitué par alkyle inférieur, alcoxy inférieur, nitro ou halogène; pyrimidine facultativement substituée par alkyle inférieur, alcoxy inférieur, nitro ou halogène; ou pyridine facultativement substituée par alkyle inférieur, alcoxy inférieur, nitro ou halogène; X, Y et Z représentent chacun indépendamment oxygène, azote ou soufre facultativement substitué par alkyle C1-7, cycloalcane C3-7 ou phényle; W représente oxygène ou soufre. De plus, l'invention concerne un procédé de production du composé de formule générale (I) ainsi qu'une composition pharmaceutique contenant une dose pharmaceutique efficace du composé de formule générale (I).