2-phenyl-N-(1,3,4-thiadiazol-2-yl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenyl-N-(1,3,4-thiadiazol-2-yl)acetamide
• 化学式: C₁₀H₉N₃OS
• mdl: MFCD00834272
• 分子量: 219.27
• InChiKey: VRCPUIHHVMQIHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Cycloalkyl-linked diheterocycle derivatives
  申请人：Pfizer Inc.

  公开号：US10676471B2

  公开（公告）日：2020-06-09

  The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

  本发明涉及式 (I) 的化合物 或其药学上可接受的盐，其中 A、L、D、R1-R15、w、x、y 和 z 在本文中定义。本发明的新型环烷基连环二杂环衍生物可用于治疗哺乳动物的异常细胞生长，如癌症。本发明还涉及含有这些化合物的药物组合物，以及使用这些化合物和组合物治疗哺乳动物异常细胞生长的方法。
• Cycloalkyl-Linked Diheterocycle Derivatives
  申请人：Pfizer Inc.

  公开号：US20190270737A1

  公开（公告）日：2019-09-05

  The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R 1 -R 15 , w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.