4-[4-(2-Methyl-1,3-thiazol-4-yl)phenyl]sulfonylmorpholine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-(2-Methyl-1,3-thiazol-4-yl)phenyl]sulfonylmorpholine
• 化学式: C₁₄H₁₆N₂O₃S₂
• 分子量: 324.4
• InChiKey: DJUXGVRQKOHTBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  96.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS<br/>[FR] MÉTHODES DE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：YUMANITY THERAPEUTICS INC

  公开号：WO2020150423A1

  公开（公告）日：2020-07-23

  The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

  本公开提供了在治疗神经系统疾病中有用的化合物和方法。本发明的化合物可以单独或与其他药用活性剂结合使用，用于治疗或预防神经系统疾病。
• [EN] SMALL MOLECULE FATTY ACID SYNTHASE INHIBITORS<br/>[FR] INHIBITEURS DE SYNTHASE D'ACIDES GRAS À PETITES MOLÉCULES
  申请人：SANFORD BURNHAM MED RES INST

  公开号：WO2015134790A1

  公开（公告）日：2015-09-11

  Provided herein are small molecule Fatty Acid Synthase Inhibitors, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

  本文提供了小分子脂肪酸合成酶抑制剂，包括这些化合物的组合物，以及使用这些化合物和包括这些化合物的组合物的方法。
• SMALL MOLECULE FATTY ACID SYNTHASE INHIBITORS
  申请人：Sanford-Burnham Medical Research Institute

  公开号：US20170066731A1

  公开（公告）日：2017-03-09

  Provided herein are small molecule Fatty Acid Synthase Inhibitors, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
• Purine Diones As Wnt Pathway Modulators
  申请人：Agency for Science, Technology and Research

  公开号：US20170334912A1

  公开（公告）日：2017-11-23

  The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R 1 , R 2 , R 3 , R 4 and R 5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
• METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Yumanity Therapeutics, Inc.

  公开号：US20200222400A1

  公开（公告）日：2020-07-16

  The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.