2,3-Difluorobenzylpiperazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-Difluorobenzylpiperazine
• 英文别名: 1-(2,3-difluoro-benzyl)-piperazine；1-(2,3-Difluorobenzyl)piperazine；1-[(2,3-difluorophenyl)methyl]piperazine
• 化学式: C₁₁H₁₄F₂N₂
• mdl: MFCD03465779
• 分子量: 212.242
• InChiKey: GBODJTRKPPKFDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INHIBITORS OF STEAROYL-COA DESATURASE
  申请人：Gillespie Paul

  公开号：US20090149466A1

  公开（公告）日：2009-06-11

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

  提供以下式(I)化合物： 以及药用可接受的盐，其中取代基如说明书中所披露。这些化合物以及包含它们的药物组合物可用于治疗诸如肥胖等疾病。
• [EN] 2,4-DIHYDROXY-NICOTINAMIDES AS APJ AGONISTS<br/>[FR] 2,4-DIHYDROXY-NICOTINAMIDES UTILISÉS EN TANT QU'AGONISTES D'APJ
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2017066402A1

  公开（公告）日：2017-04-20

  The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

  本发明提供了式（I）的化合物：其中所有变量如规范中所定义，并包括任何此类新化合物的组合物。这些化合物是APJ激动剂，可用作药物。
• Substituted bicyclic derivatives and use thereof
  申请人：Matsumoto Akiko

  公开号：US20090054401A1

  公开（公告）日：2009-02-26

  [Object] To provide a compound having prostaglandin production-suppressing action and leukotriene production-suppressing action. [Means for Solution] A compound represented by the formula (I): [In the formula, represents a single bond, or a double bond, Link represents a single bond, or a saturated or unsaturated straight hydrocarbon having 1 or 2 carbon atoms, W represents a single bond, oxygen atom, sulfur atom, N(Rw) etc., Rw represents hydrogen atom, an alkyl group having 1 to 8 carbon atoms etc, Rs represents -D-Rx etc., D represents a single bond, oxygen atom, sulfur atom etc., Rx represents a linear or branched saturated alkyl group having 3 to 8 carbon atoms etc., one of V 1 and V 2 represents Zx, and the other represents AR, Zx represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms etc., AR represents a partially unsaturated or completely unsaturated condensed bicyclic carbon ring or heterocyclic ring, and Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms etc.], or a salt thereof.

  [目标] 提供一种具有前列腺素产生抑制作用和白三烯产生抑制作用的化合物。[解决方案] 一种由式(I)表示的化合物：[在式中，表示单键或双键，Link表示单键或具有1或2个碳原子的饱和或不饱和直链碳氢化合物，W表示单键、氧原子、硫原子、N(Rw)等，Rw表示氢原子、具有1至8个碳原子的烷基等，Rs表示-D-Rx等，D表示单键、氧原子、硫原子等，Rx表示具有3至8个碳原子的线性或支链饱和烷基等，V1和V2中的一个表示Zx，另一个表示AR，Zx表示氢原子、具有1至4个碳原子的线性或支链饱和烷基等，AR表示部分不饱和或完全不饱和的螺合环碳环或杂环，Y表示氢原子、具有1至4个碳原子的低烷基等。]，或其盐。
• SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP2006271A2

  公开（公告）日：2008-12-24

  [Object] To provide a compound having prostaglandin production-suppressing action and leukotriene production-suppressing action. [Means for solution] A compound represented by the formula (I): [In the formula, ---- represents a single bond, or a double bond, Link represents a single bond, or a saturated or unsaturated straight hydrocarbon having 1 or 2 carbon atoms, W represents a single bond, oxygen atom, sulfur atom, N(Rw) etc., Rw represents hydrogen atom, an alkyl group having 1 to 8 carbon atoms etc, Rs represents -D-Rx etc., D represents a single bond, oxygen atom, sulfur atom etc., Rx represents a linear or branched saturated alkyl group having 3 to 8 carbon atoms etc., one of V1 and V2 represents Zx, and the other represents AR, Zx represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms etc., AR represents a partially unsaturated or completely unsaturated condensed bicyclic carbon ring or heterocyclic ring, and Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms etc.], or a salt thereof.

  [目的]提供一种具有抑制前列腺素生成作用和抑制白三烯生成作用的化合物。 [解决方法] 一种由式（I）表示的化合物： [式中，---- 代表单键或双键，Link 代表单键或具有 1 或 2 个碳原子的饱和或不饱和直链烃，W 代表单键、氧原子、硫原子、N(Rw)等，Rw 代表氢原子、具有 1 至 8 个碳原子的烷基等，Rs 代表-D-Rx 等，D 代表单键、氧原子、硫原子等、Rx 代表具有 3 至 8 个碳原子的直链或支链饱和烷基等，V1 和 V2 中的一个代表 Zx，另一个代表 AR，Zx 代表氢原子、具有 1 至 4 个碳原子的直链或支链饱和烷基等，AR 代表部分不饱和或完全不饱和的缩合双环碳环或杂环，Y 代表氢原子、具有 1 至 4 个碳原子的低级烷基等]，或其盐。
• Certain substituted 1-aryl-3-piperazine-1'-yl propanones
  申请人：Molecular Geriatarics Corporation

  公开号：US20010025105A1

  公开（公告）日：2001-09-27

  Disclosed are compounds of formula I: 1 wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar 1 and Ar 2 independently represent aryl groups; and Y is hydrogen; or Y and R 1 or R 2 together represent CH 2 ;CH 2 CH 2 ; CH 2 O; CH 2 S forming a five or six membered ring and such ring may be optionally substituted with loweralkyl or phenyl; or the pharmaceutically acceptable salts thereof, useful in the treatment of neoplastic diseases, and bacterial or fungal infections, and in preventing or decreasing the production of abnormally phosphorylated paired helical filament (PHF) epitopes associated with Alzheimer's Disease and, therefore, useful for treating Alzheimer's Disease.

  公开了式 I 的化合物： 1 其中 X 是羰基、磺酰基、亚甲基或被任选取代的苯基取代的亚甲基； Z 是氮或 CH； Ar 1 和 Ar 2 分别代表芳基；和 Y 是氢；或 Y 和 R 1 或 R 2 共同代表 CH 2 ;CH 2 CH 2 ；CH 2 O; CH 2 或其药学上可接受的盐，可用于治疗肿瘤性疾病、细菌或真菌感染，以及预防或减少与阿尔茨海默氏症相关的异常磷酸化成对螺旋丝（PHF）表位的产生，因此可用于治疗阿尔茨海默氏症。