(1-Methylpyridin-1-ium-3-yl)urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (1-Methylpyridin-1-ium-3-yl)urea
• 化学式: C7H10N3O+
• 分子量: 152.17
• InChiKey: YSPGTMHTWXZZGV-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  59
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• Method of treating endothelial dysfunction
  申请人：Celagenex Research (India) Pvt. Ltd.

  公开号：US10864207B2

  公开（公告）日：2020-12-15

  The present invention herein discloses potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function. Particularly, the invention relates to synergistic nutritional composition comprising exogenous blend of N1-methyl nicotinamide chloride and standardized red spinach extract enriched with nitrate content along with pharmaceutically acceptable excipients, wherein N1-methyl nicotinamide salt and standardized red spinach extract enriched with nitrate content are present in the ratio of 1:0.5 to 1:8; and N1-methyl nicotinamide chloride and nitrate of standardized red spinach extract, are present in the ratio of 1:0.1 to 1:1. The present synergistic composition is useful for treating endothelial dysfunction such as hypertension, atherosclerosis, thrombosis, myocardial infarction, heart injury.

  本发明公开了用于改善血管内皮功能的血管活性介质增强剂的强效协同组合物。特别是，本发明涉及由氯化 N1-甲基烟酰胺和富含硝酸盐的标准化红菠菜提取物以及药学上可接受的赋形剂组成的外源混合协同营养组合物，其中氯化 N1-甲基烟酰胺盐和富含硝酸盐的标准化红菠菜提取物的比例为 1:0.5 至 1:8；氯化 N1-甲基烟酰胺和标准化红菠菜提取物的硝酸盐的比例为 1:0.1 至 1:1。本增效组合物可用于治疗高血压、动脉粥样硬化、血栓形成、心肌梗塞、心脏损伤等内皮功能障碍。
• POTENT SYNERGISTIC COMPOSITIONS OF VASOACTIVE MEDIATORS ENHANCERS FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION
  申请人：Celagenex Research (India) Pvt. Ltd.

  公开号：US20200222383A1

  公开（公告）日：2020-07-16

  The present invention herein discloses potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function. Particularly, the invention relates to synergistic nutritional composition comprising exogenous blend of N 1 -methyl nicotinamide chloride and standardized red spinach extract enriched with nitrate content along with pharmaceutically acceptable excipients, wherein N 1 -methyl nicotinamide salt and standardized red spinach extract enriched with nitrate content are present in the ratio of 1:0.5 to 1:8; and N 1 -methyl nicotinamide chloride and nitrate of standardized red spinach extract, are present in the ratio of 1:0.1 to 1:1. The present synergistic composition is useful for treating endothelial dysfunction such as hypertension, atherosclerosis, thrombosis, myocardial infarction, heart injury.
• [EN] POTENT SYNERGISTIC COMPOSITIONS OF VASOACTIVE MEDIATORS ENHANCERS FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION<br/>[FR] COMPOSITIONS SYNERGIQUES PUISSANTES DE MÉDIATEURS VASOACTIFS FAVORISANT LA FONCTION ENDOTHÉLIALE VASCULAIRE
  申请人：CELAGENEX RES INDIA PVT LTD

  公开号：WO2020141552A1

  公开（公告）日：2020-07-09

  The present invention herein discloses potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function. Particularly, the invention relates to synergistic nutritional composition comprising exogenous blend of N1-methyl nicotinamide chloride and standardized red spinach extract enriched with nitrate content along with pharmaceutically acceptable excipients, wherein N1-methyl nicotinamide salt and standardized red spinach extract enriched with nitrate content are present in the ratio of 1: 0.5 to 1: 8; and N1-methyl nicotinamide chloride and nitrate of standardized red spinach extract, are present in the ratio of 1: 0.1 to 1: 1. The present synergistic composition is useful for treating endothelial dysfunction such as hypertension, atherosclerosis, thrombosis, myocardial infarction, heart injury.