N-tert-butyl-6-methyl-2-pyridin-3-ylimidazo[1,2-a]pyridin-3-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: N-tert-butyl-6-methyl-2-pyridin-3-ylimidazo[1,2-a]pyridin-3-amine
• 化学式: C₁₇H₂₀N₄
• 分子量: 280.373
• InChiKey: RRMIVSHLUMVDKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-吡啶甲醛 、 2-氨基-5-甲基吡啶 、 异氰酸叔丁酯 在 高氯酸 作用下， 以 甲醇 为溶剂， 以98%的产率得到N-tert-butyl-6-methyl-2-pyridin-3-ylimidazo[1,2-a]pyridin-3-amine
  参考文献：
  名称：

  A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-Aminoimidazoles

  摘要：

  When general and reliable, multicomponent reactions are among the most powerful tools in modern drug discovery. The principle of chemical ligation of reactive partners (see reaction scheme) has been employed to find a new, highly efficient synthesis of fused 3-aminoimidazoles.

  DOI：

  10.1002/(sici)1521-3773(19980904)37:16<2234::aid-anie2234>3.0.co;2-r

文献信息

• VERWENDUNG VON SUBSTITUIERTEN IMIDAZO [1,2-A]PYRIDIN-, -PYRIMIDIN- UND -PYRAZIN-3-YL-AMIN-DERIVATEN ZUR HERSTELLUNG VON MEDIKAMENTEN ZUR NOS-INHIBIERUNG
  申请人：Grünenthal GmbH

  公开号：EP1326613B1

  公开（公告）日：2004-06-02
• Use of substituted imidazo[1,2-a]-pyridin-, -pyrimidin-and-pyrazin-3-yl-amine derivatives in the preparation of medicaments for inhibiting NOS
  申请人：Gruenenthal GmbH

  公开号：US20040023972A1

  公开（公告）日：2004-02-05

  A pharmaceutical composition for the treatment of pain, migraine, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, cerebral ischaemia, diabetes, meningitis, or arteriosclerosis, or a method for healing wounds, the method comprising administering to a patient in need thereof an effective amount of a pharmaceutical composition comprising a compound of formula I 1 Also disclosed are methods of preparing the compounds of formula I, and treatment methods using the pharmaceutical compositions.
• [DE] SUBSTANZBIBLIOTHEK ENTHALTEND BICYCLISCHE IMIDAZO-5-YL-AMINE UND/ODER BICYCLISCHE IMIDAZO-3-YL-AMINE<br/>[EN] SUBSTANCE LIBRARY CONTAINING BICYCLIC IMIDAZO-5-YL-AMINES AND/OR BICYCLIC IMIDAZO-3-YL-AMINES<br/>[FR] BIBLIOTHEQUE DE SUBSTANCES CONTENANT DES IMIDAZO-5-YL-AMINES BICYCIQUES ET/OU DES IMIDAZO-3-YL-AMINES BICYCLIQUES
  申请人：GRUENENTHAL GMBH

  公开号：WO2001027119A2

  公开（公告）日：2001-04-19

  Substanzbibliothek enthaltend bicyclische Imidazo-5-yl-amine und/oder bicyclische Imidazo-3-yl-amine der allgemeinen Formeln (I) bzw. (II), ein Verfahren zur Herstellung dieser Substanzbibliothek sowie die Verwendung von Substanzen aus dieser Substanzbibliothek zur Herstellung eines Arzneimittels zur Behandlung von Schmerz.
• A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-Aminoimidazoles
  作者：Hugues Bienaymé、Kamel Bouzid

  DOI：10.1002/(sici)1521-3773(19980904)37:16<2234::aid-anie2234>3.0.co;2-r

  日期：1998.9.4

  When general and reliable, multicomponent reactions are among the most powerful tools in modern drug discovery. The principle of chemical ligation of reactive partners (see reaction scheme) has been employed to find a new, highly efficient synthesis of fused 3-aminoimidazoles.