2,2,6-Trimethyl-6-[2-[2-[2-[2-[(2,2,6-trimethyl-7-oxo-1,4-diazabicyclo[3.2.0]heptan-6-yl)oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,4-diazabicyclo[3.2.0]heptan-7-one | 320351-10-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂卓
• 英文名称: 2,2,6-Trimethyl-6-[2-[2-[2-[2-[(2,2,6-trimethyl-7-oxo-1,4-diazabicyclo[3.2.0]heptan-6-yl)oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,4-diazabicyclo[3.2.0]heptan-7-one
• CAS: 320351-10-8
• 化学式: C₂₄H₄₂N₄O₇
• 分子量: 498.62
• InChiKey: HOVGGOFOTULPTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  35
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2,2,6-Trimethyl-6-[2-[2-[2-[2-[(2,2,6-trimethyl-7-oxo-1,4-diazabicyclo[3.2.0]heptan-6-yl)oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,4-diazabicyclo[3.2.0]heptan-7-one 在 camphor-10-sulfonic acid 、 溴甲酚绿 、 sodium cyanoborohydride 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 反应 72.0h， 以35%的产率得到(1R,15R)-1,15,18,18,24,24-Hexamethyl-2,5,8,11,14-pentaoxa-17,20,23,26-tetraaza-bicyclo[13.6.6]heptacosane-16,22-dione
  参考文献：
  名称：

  Synthesis and Complexation Properties of Poly(ethylene glycol)-Linked Mono- and Bis-dioxocyclams

  摘要：

  Both tri- and tetra(ethylene glycol) linked bis-chromium carbene complexes have been synthesized. These carbene complexes were photolyzed with N-protected imidazolines to give protected azapenams. These were transformed into polyether-linked basket dioxacyclams 4a,b and bis-dioxocyclams 5a,b. These compounds have-cavities for the complexation of both "hard" and "soft" metal ions.;The complexes of Ni, Ba, and Gd were synthesized.

  DOI：

  10.1021/jo001095q
• 作为产物：
  描述：

  4,4-二甲基-2-咪唑并啉 在 10percent Pd/C 氢气 、 三甲基乙酰氯 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， -40.0~55.0 ℃ 、551.59 kPa 条件下， 反应 9.5h， 生成 2,2,6-Trimethyl-6-[2-[2-[2-[2-[(2,2,6-trimethyl-7-oxo-1,4-diazabicyclo[3.2.0]heptan-6-yl)oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,4-diazabicyclo[3.2.0]heptan-7-one
  参考文献：
  名称：

  Synthesis and Complexation Properties of Poly(ethylene glycol)-Linked Mono- and Bis-dioxocyclams

  摘要：

  Both tri- and tetra(ethylene glycol) linked bis-chromium carbene complexes have been synthesized. These carbene complexes were photolyzed with N-protected imidazolines to give protected azapenams. These were transformed into polyether-linked basket dioxacyclams 4a,b and bis-dioxocyclams 5a,b. These compounds have-cavities for the complexation of both "hard" and "soft" metal ions.;The complexes of Ni, Ba, and Gd were synthesized.

  DOI：

  10.1021/jo001095q