1-(3,4-Dimethoxyphenyl)-1-cyclohexanecarboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3,4-Dimethoxyphenyl)-1-cyclohexanecarboxamide
• 英文别名: 1-(3,4-dimethoxyphenyl)cyclohexane-1-carboxamide
• 化学式: C₁₅H₂₁NO₃
• 分子量: 263.33
• InChiKey: ZUYMXBMGAFZKDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CONTAINING CYCLOALKYL OR PYRANYL GROUPS
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1680411A2

  公开（公告）日：2006-07-19
• [EN] MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS<br/>[FR] MODULATEURS DES TRANSPORTEURS DES CASSETTES DE FIXATION DE L'ATP
  申请人：VERTEX PHARMA

  公开号：WO2005035514A2

  公开（公告）日：2005-04-21

  The present invention provides compounds of Formula (I) useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula (I), useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.