1-(4-Chlorobenzyl)-4-(3-methylbenzyl)piperazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-Chlorobenzyl)-4-(3-methylbenzyl)piperazine
• 英文别名: 1-[(4-chlorophenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
• 化学式: C₁₉H₂₃ClN₂
• 分子量: 314.9
• InChiKey: CXEOXHFRVSMJHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Deuterated Meclizine
  申请人：CONCERT Pharmaceuticals, Inc.

  公开号：US20180208566A1

  公开（公告）日：2018-07-26

  This invention relates to deuterated forms of meclizine, and pharmaceutically acceptable salts or hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering meclizine and other Constitutive Androstane Receptor agonists or FGFR3 antagonists.