Cambridge id 6634849

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Cambridge id 6634849
• 英文别名: (2-chloro-4-methylphenyl)-(4-methylpiperazin-1-yl)methanone
• 化学式: C₁₃H₁₇ClN₂O
• 分子量: 252.74
• InChiKey: DVURSJQZULCRFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN
  申请人：Genentech, Inc.

  公开号：EP3218375B1

  公开（公告）日：2022-04-27
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：GENENTECH, INC.

  公开号：US20170340605A1

  公开（公告）日：2017-11-30

  The present invention relates to compounds of formula (I): and to salts thereof, wherein R 1 , R 2 , and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.