2-(2-Nitrophenyl)sulfonylbenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-Nitrophenyl)sulfonylbenzoic acid
• 化学式: C13H9NO6S
• 分子量: 307.28
• InChiKey: WOEQJEQPTQHJIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  126
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Process for preparing dibenzothiazepine compounds
  申请人：Murray Michael Paul

  公开号：US20070203336A1

  公开（公告）日：2007-08-30

  A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2′-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2′-carboxy-diphenylsulfide compound is suitably prepared by reducing a 2-nitro-2′-carboxy-diphenylsulfide compound in a lower aliphatic ester solvent; and the 2-nitro-2′-carboxy-diphenylsulfide compound is suitably prepared by reacting a nitrobenzene compound with a thiosalicylic acid compound in a mixture of a lower aliphatic alcohol and water.

  通过在酸性催化剂的存在下，将2-氨基-2'-羧基二苯硫醚化合物进行脱水缩合反应，可以适当地制备二苯并噻吩类化合物；2-氨基-2'-羧基二苯硫醚化合物可以通过在较低的脂肪酯溶剂中还原2-硝基-2'-羧基二苯硫醚化合物来适当地制备；而2-硝基-2'-羧基二苯硫醚化合物可以通过在较低脂肪醇和水的混合物中，将硝基苯化合物与硫代水杨酸类化合物反应来适当地制备。
• Method of preparing 10th-dibenzo[b,f][11,4]thiazepin-11-one
  申请人：Kwak Byong-Sung

  公开号：US20070066589A1

  公开（公告）日：2007-03-22

  Disclosed is a method of preparing 10H-dibenzo[b,f][1,4]thiazepin-11-one, including reacting dithiosalicylic acid with 1-chloro-2-nitrobenzene in a basic aqueous solution in the presence or absence of a reducing agent, to prepare 2-(2-nitrophenylsulfuryl)benzoic acid; subjecting the 2-(2-nitrophenylsulfuryl)benzoic acid to nitro group reduction in the presence of hydrogen, a solvent and a heterogeneous metal catalyst, to prepare 2-(2-aminophenylsulfuryl)benzoic acid; and directly cyclizing the 2-(2-aminophenylsulfuryl)benzoic acid in an organic solvent in the presence or absence of an acid catalyst. The method according to the present invention is economical due to the use of the inexpensive starting material, and also environmentally friendly and efficient by minimizing the use of the organic solvent and performing direct cyclization without the activation of carboxylic acid.

  本发明公开了一种制备10H-二苯并[b，f][1,4]噻吩-11-酮的方法，包括在碱性水溶液中存在或不存在还原剂的情况下，将二硫基水杨酸与1-氯-2-硝基苯反应，制备2-(2-硝基苯基磺酰基)苯甲酸；在氢气、溶剂和异相金属催化剂的存在下，对2-(2-硝基苯基磺酰基)苯甲酸进行硝基还原，制备2-(2-氨基苯基磺酰基)苯甲酸；并在有机溶剂存在或不存在酸性催化剂的情况下，直接环化2-(2-氨基苯基磺酰基)苯甲酸。本发明的方法由于使用了廉价的起始材料，因此经济实惠，并且通过最小化有机溶剂的使用和在不激活羧酸的情况下进行直接环化，具有环保和高效的特点。
• METHOD OF PREPARING 10H-DIBENZO b,f 1,4 THIAZEPIN-11-ONE
  申请人：SK Corporation

  公开号：EP1565448A2

  公开（公告）日：2005-08-24
• EP1565448A4
  申请人：——

  公开号：EP1565448A4

  公开（公告）日：2008-04-23
• PROCESS FOR PREPARING DIBENZOTHIAZEPINE COMPOUNDS
  申请人：AstraZeneca UK Limited

  公开号：EP1996568A2

  公开（公告）日：2008-12-03