5-chloro-N-(4-fluorobenzyl)thiophene-2-sulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-chloro-N-(4-fluorobenzyl)thiophene-2-sulfonamide
• 英文别名: 5-chloro-N-[(4-fluorophenyl)methyl]thiophene-2-sulfonamide
• 化学式: C₁₁H₉ClFNO₂S₂
• 分子量: 305.8
• InChiKey: ZNPLATXSNFHJOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  82.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Small molecule antimicrobials
  申请人：Ohio State Innovation Foundation

  公开号：US11046668B2

  公开（公告）日：2021-06-29

  Compounds and compositions of matter are provided that are small molecule antimicrobials. The compounds are selected from JH-144, TH-04 or TH-08 or combinations thereof. Compositions of matter are provided which in an embodiment may comprise a carrier, and in further embodiments may comprise a pharmaceutically acceptable excipient, film, biofilm or edible film. Methods of use are provided in which the composition may be administered to a subject in need thereof, and in an embodiment where the subject has a bacterial infection. Other embodiments provide the composition may be contacted with surface to eliminate or reduce bacteria.

  所提供的化合物和物质组合物是小分子抗菌剂。这些化合物选自 JH-144、TH-04 或 TH-08 或其组合。本发明提供的物质组合物在一个实施方案中可包括载体，在另一个实施方案中可包括药学上可接受的赋形剂、薄膜、生物膜或可食用薄膜。本发明提供了使用方法，其中组合物可施用给有需要的受试者，在一个实施方案中，受试者患有细菌感染。其他实施方案中，组合物可与表面接触，以消除或减少细菌。
• NOVEL SMALL MOLECULE ANTIMICROBIALS
  申请人：Ohio State Innovation Foundation

  公开号：US20200299259A1

  公开（公告）日：2020-09-24

  Compounds and compositions of matter are provided that are small molecule antimicrobials. The compounds are selected from JH-144, TH-04 or TH-08 or combinations thereof. Compositions of matter are provided which in an embodiment may comprise a carrier, and in further embodiments may comprise a pharmaceutically acceptable excipient, film, biofilm or edible film. Methods of use are provided in which the composition may be administered to a subject in need thereof, and in an embodiment where the subject has a bacterial infection. Other embodiments provide the composition may be contacted with surface to eliminate or reduce bacteria.