1-Methyl-octahydro-cyclopentapyrrol | 92383-30-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Methyl-octahydro-cyclopentapyrrol
• 英文别名: 1-methyl-octahydro-cyclopenta[b]pyrrole；1-methyl-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole
• CAS: 92383-30-7
• 化学式: C₈H₁₅N
• 分子量: 125.214
• InChiKey: PQNRHZQICCJMJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• BIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS
  申请人：HOLTMAN Joseph R.

  公开号：US20110166177A1

  公开（公告）日：2011-07-07

  Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.

  提供了使用双季铵化合物治疗炎症性疼痛、神经病理性疼痛和伤害性疼痛的方法。
• Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：US20160095858A1

  公开（公告）日：2016-04-07

  The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R 1 , R 2 , R 3 , W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

  本发明涉及一种具有以下化学式I的化合物： 或其药用可接受的盐，其中R 1 ，R 2 ，R 3 ，W，X，Y，Z，n，o，p和q在此处定义，用于治疗CFTR介导的疾病，如囊性纤维化。本发明还涉及药物组合物、治疗方法和相关工具包。
• TETRAKIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACTEYLCHOLINE RECEPTORS
  申请人：CROOKS PETER A.

  公开号：US20090143424A1

  公开（公告）日：2009-06-04

  Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.

  提供了四季铵化合物，它们是尼古丁型乙酰胆碱受体的调节剂。还提供了使用这些化合物调节尼古丁型乙酰胆碱受体功能的方法，以及用于预防和/或治疗中枢神经系统疾病、物质使用和/或滥用，以及/或胃肠道疾病的方法。
• BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
  申请人：Crooks Peter

  公开号：US20090318503A1

  公开（公告）日：2009-12-24

  Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.

  提供的是双季铵化合物，它们是尼古丁型乙酰胆碱受体的调节剂。还提供了使用这些化合物调节尼古丁型乙酰胆碱受体功能的方法，以及用于预防和/或治疗中枢神经系统疾病、物质使用和/或滥用，以及/或胃肠道疾病的方法。
• N-SUBSTITUTED AMINOBENZOCYCLOHEPTENE, AMINOTETRALINE, AMINOINDANE AND PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：US20130131132A1

  公开（公告）日：2013-05-23

  The present invention relates to N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives of the formula (I), (II), (III) or (IV) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, and the use of such N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives for therapeutic purposes. The N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives are GlyT1 inhibitors.

  本发明涉及式(I)、(II)、(III)或(IV)所示的N-取代氨基苯并环庚烯、氨基四氢异喹啉、氨基吲哚和苯基烷基胺衍生物 或其生理耐受盐。 该发明涉及包含上述N-取代氨基苯并环庚烯、氨基四氢异喹啉、氨基吲哚和苯基烷基胺衍生物的药物组合物，以及将上述N-取代氨基苯并环庚烯、氨基四氢异喹啉、氨基吲哚和苯基烷基胺衍生物用于治疗用途。所述N-取代氨基苯并环庚烯、氨基四氢异喹啉、氨基吲哚和苯基烷基胺衍生物是甘氨酸转运体1抑制剂。