(E)-3-(1,3-benzodioxol-5-yl)-N-cyclooctylprop-2-enamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (E)-3-(1,3-benzodioxol-5-yl)-N-cyclooctylprop-2-enamide
• 化学式: C₁₈H₂₃NO₃
• 分子量: 301.4
• InChiKey: GDLZFCOVNATXDY-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS
  申请人：Johnson James Andrew

  公开号：US20100179124A1

  公开（公告）日：2010-07-15

  A series of thieno[2,3-b]pyridine derivatives which are substituted in the 2-position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.

  一系列在2位被取代的苯胺基团取代的噻吩[2,3-b]吡啶衍生物，是人类MEK (MAPKK)酶的选择性抑制剂，在医学上具有益处，例如在治疗炎症、自身免疫、心血管、增殖性（包括肿瘤）和疼痛性疾病方面。
• USE OF PIPERINE AND DERIVATIVES THEREOF FOR THE THERAPY OF NEUROLOGICAL CONDITIONS
  申请人：Sygnis Bioscience GmbH & Co. KG

  公开号：EP2170320A1

  公开（公告）日：2010-04-07
• US8350037B2
  申请人：——

  公开号：US8350037B2

  公开（公告）日：2013-01-08
• [EN] USE OF PIPERINE AND DERIVATIVES THEREOF FOR THE THERAPY OF NEUROLOGICAL CONDITIONS<br/>[FR] UTILISATION DE LA PIPÉRINE ET DE SES DÉRIVÉS EN THÉRAPIE POUR TRAITER LES AFFECTIONS NEUROLOGIQUES
  申请人：SYGNIS BIOSCIENCE GMBH & CO KG

  公开号：WO2009004071A1

  公开（公告）日：2009-01-08

  The present invention relates to the use of piperine and derivatives thereof for the preparation of a pharmaceutical composition for treating and/or preventing a neuronal condition where there is a need of neuroprotection and/or neuroregeneration. The invention furthermore relates to the use of piperine and derivatives thereof for the in vitro differentiation of neural stem cells and the use of such pre-treated cells for stem cell therapy von neurological conditions.