N-[4-(morpholine-4-carbonyl)phenyl]furan-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(morpholine-4-carbonyl)phenyl]furan-2-carboxamide
• 化学式: C₁₆H₁₆N₂O₄
• mdl: MFCD01993199
• 分子量: 300.31
• InChiKey: YNUMVRJFHUQIMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE
  申请人：University of Kansas

  公开号：US20150203477A1

  公开（公告）日：2015-07-23

  N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

  提供了N-取代磺酰基苯基-5-硝基呋喃-2-羧酰胺衍生物化合物，其选择性激活蛋白质错配反应的凋亡分支而非适应性分支，并且可以用于治疗糖尿病、阿尔茨海默病、帕金森病、血友病、溶酶体贮积病和癌症。
• Compounds and methods for activating the apoptotic arm of the unfolded protein response
  申请人：University of Kansas

  公开号：US10787439B2

  公开（公告）日：2020-09-29

  N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

  提供了 N-取代磺酰基苯基-5-硝基呋喃基-2-甲酰胺衍生化合物，这些化合物可选择性地激活折叠蛋白反应的凋亡臂而非适应臂，并可用于治疗糖尿病、阿尔茨海默氏症、帕金森氏症、血友病、溶酶体贮积症和癌症等疾病。
• US9732067B2
  申请人：——

  公开号：US9732067B2

  公开（公告）日：2017-08-15