[4-(Acetamidomethyl)-2-acetyloxyphenyl] acetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: [4-(Acetamidomethyl)-2-acetyloxyphenyl] acetate
• 化学式: C₁₃H₁₅NO₅
• 分子量: 265.26
• InChiKey: KIYMCVJRHUWTHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compounds, Compositions and Methods for the Treatment of Amyloid Diseases and Synucleinopathies such as Alzheimer's Disease, Type 2 Diabetes and Parkinson's Disease
  申请人：SNOW Alan D.

  公开号：US20110172239A1

  公开（公告）日：2011-07-14

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双-和三-二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的制药组合物，以及它们在治疗淀粉样疾病，特别是阿尔茨海默病中观察到的Aβ淀粉样蛋白病，IAPP淀粉样蛋白病，如在2型糖尿病中观察到的和突触核蛋白病，如在帕金森病中观察到的用途，以及制造此类治疗药物。
• US8163957B2
  申请人：——

  公开号：US8163957B2

  公开（公告）日：2012-04-24