4-(furan-2-yl)-6-(4-methoxyphenyl)-2-sulfanylidene-1H-pyridine-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(furan-2-yl)-6-(4-methoxyphenyl)-2-sulfanylidene-1H-pyridine-3-carbonitrile
• 化学式: C₁₇H₁₂N₂O₂S
• 分子量: 308.36
• InChiKey: ABFHFWNIHBVTNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  90.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(furan-2-yl)-6-(4-methoxyphenyl)-2-sulfanylidene-1H-pyridine-3-carbonitrile 在 硫酸氢铵 、 四氯化锡 作用下， 以 乙腈 为溶剂， 生成 Acetic acid (2R,3R,4S,5R)-4,5-diacetoxy-2-[3-cyano-4-furan-2-yl-6-(4-methoxy-phenyl)-2-thioxo-2H-pyridin-1-yl]-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  Synthesis and Antiviral Activity of SomeN-Pentopyranosyl-2-Pyridinethiones

  摘要：

  A novel synthesis of 1-(beta-D-pentopyranosyl)pyridinethione nucleosides utilizing pyridine-2(1H)-thiones and alpha-bromoxylose or beta-bromoarabinose triacetate as starting components is described. The free nucleosides were tested for their potential activity against HIV and different types of tumor virus.

  DOI：

  10.1080/15257779508009493

文献信息

• Attia, Adel M. E.; Ibrahim, Elsayed I.; Hay, Fouad E. A., Organic Preparations and Procedures International, 1995, vol. 27, # 6, p. 613 - 620
  作者：Attia, Adel M. E.、Ibrahim, Elsayed I.、Hay, Fouad E. A.、Abbasi, Mohammed M. A.、Mansour, Hanaa A. E.

  DOI：——

  日期：——
• Antibacterial fab i inhibitors
  申请人：Moir T. Donald

  公开号：US20070027190A1

  公开（公告）日：2007-02-01

  Disclosed herein are antibacterial compounds that inhibit fabl, a NADH-dependent enoyl [acyl carrier protein] reductase enzyme in the fatty acid biosynthesis pathway. The compounds are represented by structural formulas Ia and Ib: R1 and R2 are independently monocyclic aryl or heteroaryl groups, wherein the groups represented by R1 and R2 are optionally substituted with one or more acyclic substituents; R3 is —H or an optionally substituted C1-C8 aliphatic, C3-C8 cycloaliphatic, aryl, or heteroaryl group. X1 is a bond or a C1-C3 alkylene chain that is optionally substituted with a C1-C4 alkyl or an acidic group. X2 is an aryl, heteroaryl or C3-C8 cycloaliphatic ring, wherein the group represented by X2 is optionally substituted with triazole, tetrazole, and/or one or more acyclic substituents.
• Synthesis and Antiviral Activity of Some<i>N</i>-Pentopyranosyl-2-Pyridinethiones
  作者：Adel M. E. M. Attia、Elsayed I. Ibrahim、Fouad E. A. Hay、Mohammed M. A. Abbasi、Hanaa A. E. Mansour

  DOI：10.1080/15257779508009493

  日期：1995.9

  A novel synthesis of 1-(beta-D-pentopyranosyl)pyridinethione nucleosides utilizing pyridine-2(1H)-thiones and alpha-bromoxylose or beta-bromoarabinose triacetate as starting components is described. The free nucleosides were tested for their potential activity against HIV and different types of tumor virus.