3-(2-methoxy-phenyl)-6-(3-nitro-phenyl)-3,4-dihydro-1H-pyrimidin-2-one | 36945-90-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-methoxy-phenyl)-6-(3-nitro-phenyl)-3,4-dihydro-1H-pyrimidin-2-one
• 英文别名: 1-(2'-methoxyphenyl)-4-(3''-nitrophenyl)-1,2,3,6-tetrahydropyrimidine-2-one；1-(2'-methoxy)-4-(3''-nitrophenyl)-1,2,3,6-tetrahydropyrimidine-2-one；3-(2-Methoxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one
• CAS: 36945-90-1
• 化学式: C₁₇H₁₅N₃O₄
• 分子量: 325.324
• InChiKey: JIAGZNMPGSZKSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel compounds and their uses
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20040067970A1

  公开（公告）日：2004-04-08

  Use of a compound according to Formula [I]: 1 or a salt thereof to produce a cooling sensation, wherein R 1 and R 2 are independently selected from hydrogen or halogen atoms; hydroxy, cyano, nitro, mercapto, carbonyl, sulfone and carboxy groups: or optionally substituted alkyl, alkenyl, alkoxy, alkylthio, aryl, aryloxy, arylthio, amino, siloxy, ester and heterocyclic groups, with the proviso that when R 1 is 2-hydroxyphenyl, R 2 is other than 3-nitrophenyl.

  使用式[I]中的化合物或其盐可产生冷却感，其中R1和R2分别选择自氢原子或卤素原子；羟基、氰基、硝基、巯基、羰基、砜基和羧基基团；或者是选择性取代的烷基、烯基、烷氧基、烷硫基、芳基、芳氧基、芳硫基、氨基、硅氧基、酯基和杂环基团，但是当R1为2-羟基苯基时，R2不能为3-硝基苯基。
• Combination compositions and their use in methods for treating obesity and obesity-related disorders
  申请人：Helmholtz Zentrum Munchen—Deutsches Forschungszentrum fur Gesundheit Und Umwelt (GMBH)

  公开号：US10568852B2

  公开（公告）日：2020-02-25

  The present invention relates to compositions comprising at least two different active compounds and the use of such combination compositions in medicine, in particular in methods for treating obesity and obesity-related disorders and/or in methods for inhibiting weight gain.

  本发明涉及包含至少两种不同活性化合物的组合物，以及这种组合物在医学中的应用，特别是在治疗肥胖和肥胖相关疾病的方法和/或抑制体重增加的方法中的应用。
• Compound delivery systems
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20040151674A1

  公开（公告）日：2004-08-05

  A composition comprising (a) from 0.005% to 0.5% by weight of a cooling compound; (b) from 0.1% to 10% by weight of an emulsifiable substance; (c) from 0.15% to 15% by weight of a surfactant; (d) optionally up to 5% by weight, preferably from 0.05% to 5% by weight of a cosurfactant.

  一种组合物，包括 (a) 按重量计 0.005%至 0.5%的冷却化合物； (b) 0.1%至 10%（按重量計）的可乳化物； (c) 0.15%至 15%（按重量计）的表面活性剂； (d) 以重量计，可选择不超过 5%，最好是 0.05%至 5%的共表面活性剂。
• TETRAHYDROPYRIMIDINE-2-ONE DERIVATIVES AND THEIR USES
  申请人：UNILEVER PLC

  公开号：EP1546114A1

  公开（公告）日：2005-06-29
• COMPOUND DELIVERY SYSTEMS COMPRISING A COOLING COMPOUND SUCH AS MENTHOL OR ICILIN
  申请人：UNILEVER PLC

  公开号：EP1572141A1

  公开（公告）日：2005-09-14