N-(benzyloxycarbonyl)-2-phenylmethyl-3-piperidone | 276872-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(benzyloxycarbonyl)-2-phenylmethyl-3-piperidone
• 英文别名: Benzyl 2-benzyl-3-oxopiperidine-1-carboxylate
• CAS: 276872-92-5
• 化学式: C₂₀H₂₁NO₃
• 分子量: 323.392
• InChiKey: DCGIGTCUEYOURR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(benzyloxycarbonyl)-2-phenylmethyl-3-piperidone 在 三甲基氯硅烷 、 lithium hexamethyldisilazane 、 palladium diacetate 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 生成 benzyl 6-benzyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate
  参考文献：
  名称：

  Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

  摘要：

  Screening of our in-house compound library comprised of intermediates of natural product synthesis projects resulted in discovering two novel gamma-secretase inhibitors, which coincidently had similar moieties, that is, cyclohexenone and two aryl groups arranged on the core six-membered ring. Structure-activity relationship studies of these compounds were also developed. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.04.025
• 作为产物：
  描述：

  N-[1-Benzyl-2-hydroxy-5-(tetrahydro-pyran-2-yloxy)-pentyl]-2-nitro-benzenesulfonamide 在 吡啶 、 邻苯二甲酸二甲酯 、 camphor-10-sulfonic acid 、 potassium carbonate 、 caesium carbonate 、 苯硫酚 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 甲醇 、 二氯甲烷 、 甲苯 、 乙腈 为溶剂， 生成 N-(benzyloxycarbonyl)-2-phenylmethyl-3-piperidone
  参考文献：
  名称：

  Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

  摘要：

  Screening of our in-house compound library comprised of intermediates of natural product synthesis projects resulted in discovering two novel gamma-secretase inhibitors, which coincidently had similar moieties, that is, cyclohexenone and two aryl groups arranged on the core six-membered ring. Structure-activity relationship studies of these compounds were also developed. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.04.025

文献信息

• Heterocycyclic piperidines as modulators of chemokine receptor activity
  申请人：——

  公开号：US06331545B1

  公开（公告）日：2001-12-18

  The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

  本申请描述了公式 (I) 的CCR3调节剂或其药用盐形式，可用于预防哮喘和其他过敏疾病。
• Heterocyclic piperidines as modulators of chemokine receptor activity
  申请人：——

  公开号：US20020119980A1

  公开（公告）日：2002-08-29

  The present application describes modulators of CCR3 of formula (I): 1 or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

  本申请描述了CCR3的调节剂的公式(I):1或其药学上可接受的盐形式，用于预防哮喘和其他过敏性疾病。
• HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
  申请人：Ko S. Soo

  公开号：US20070299057A9

  公开（公告）日：2007-12-27

  The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.

  本申请描述了CCR3调节剂的化学式(I)或其药学上可接受的盐形式，可用于预防哮喘和其他过敏性疾病。
• US6331545B1
  申请人：——

  公开号：US6331545B1

  公开（公告）日：2001-12-18
• US6759411B2
  申请人：——

  公开号：US6759411B2

  公开（公告）日：2004-07-06